Fischerisin A and B, cytotoxic sesquiterpenoid-geranylhydroquinones from Ligularia fischeri.

Abstract

During the course of screening natural sesquiterpenoids for new antitumor agents, two novel compounds, fischerisin A (1) and fischerisin B (2), were isolated from the roots of Ligularia fischeri. Their structures were elucidated by interpretation of their IR, high resolution-mass spectrometry (HR-MS), 1D- and 2D-NMR data. Fischerisin A and B are the first representatives of a novel sesquiterpenoid-geranylhydroquinone hybrid, and both compounds exhibited in vitro cytotoxicity against cultured human oral epidermoid carcinoma (KB) and human breast cancer (MCF-7) cell lines with IC(50) values of 9.7 and 10.2 µM, and 9.8 and 17.8 µM, respectively.

• Authors: Wei-Dong Xie, Xia Li, Cheng-Wu Weng, Shan-Shan Liu, Kyung Ho Row
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 59 Issue 4 Pg. 511-4 ( 2011) ISSN: 1347-5223 [Electronic] Japan
• PMID: 21467686 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Sesquiterpenes
• Terpenes
• fischerisin A
• fischerisin B
• geranylhydroquinone

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, toxicity)
• Asteraceae (chemistry)
• Cell Line, Tumor
• Drug Screening Assays, Antitumor
• Humans
• Magnetic Resonance Spectroscopy
• Plant Roots (chemistry)
• Sesquiterpenes (chemistry, isolation & purification, pharmacology, toxicity)
• Spectrophotometry, Infrared
• Terpenes (chemistry, isolation & purification, toxicity)