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2-Aryl-1,4-naphthoquinone-1-oxime methyl ethers: their cytotoxic activity.

Abstract
Preliminary examination for the structure-activity relationship of quinone monooxime derivatives on cytotoxicity against HeLa S3 cell and further trials using eight different cell lines suggested that 2-aryl-6,7-methylenedioxy-1,4-naphthoquinone-1-oxime methyl ethers, carrying 2-methoxy-4,5-methylenedioxyphenyl, 7-methoxy-2-methylbenzofuran-4-yl, and 2-methoxycarbonyl-3,4-dimethoxyphenyl as the 2-aryl substituent, were potential candidates for anti-cancer drugs.
AuthorsTsutomu Ishikawa, Tatsuru Saito, Ayako Kurosawa, Toshiko Watanabe, Sakiko Maruyama, Yuh-ichiro Ichikawa, Ryota Yamada, Hiroko Okuzawa, Hiromi Sato, Koichi Ueno
JournalChemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 59 Issue 4 Pg. 472-5 ( 2011) ISSN: 1347-5223 [Electronic] Japan
PMID21467676 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Methyl Ethers
  • Naphthoquinones
  • Oximes
  • 1,4-naphthoquinone
Topics
  • Antineoplastic Agents (chemistry, isolation & purification, toxicity)
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Humans
  • Methyl Ethers (chemistry)
  • Naphthoquinones (chemistry, toxicity)
  • Oximes (chemistry, toxicity)
  • Structure-Activity Relationship

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