The value of proton MR-spectroscopy in the differentiation of brain tumours from non-neoplastic brain lesions.

Abstract

PURPOSE:

Our aim was to evaluate the efficacy of Proton-MR Spectroscopy for the differentiation of cranial masses from non-neoplastic brain disorders.

MATERIAL AND METHOD:

33 patients with intracranial mass lesions, 29 patients with non-neoplastic brain lesions: Ischemic-demyelinating-metabolic-benign cystic mass group; As a whole 62 patients: 30 males and 32 females were included in this study.

RESULTS:

In brain tumours, average Cho/NAA ratio 2.84-NAA/Cr ratio was 0.97, Cho/Cr ratio 2.42 and Cho/MI ratio was 3.51. In non-neoplastic group; NAA/Cr ratio was extremely higher than tumour group, the other ratios were far lower than cranial mass lesions. Average Cho/NAA ratio: 0.50 +/- 0.15, Cho/Cr ratio: 1.05 +/- 0.14, Cho/MI ratio: 1.07 +/- 0.73.

CONCLUSION:

Higher Cho/NAA and Cho/MI ratios with lower NAA/Cr ratio were most likely to be malignant. Additional lipid and lactate peaks were generally seen in malignant group.

• Authors: H Aydin, S Sipahioğlu, N Aydin Oktay, E Altin, V Kizilgöz, B Hekimoglu
• Journal: JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (JBR-BTR) 2011 Jan-Feb Vol. 94 Issue 1 Pg. 1-10 ISSN: 0302-7430 [Print] Belgium
• PMID: 21466053 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Protons
• Aspartic Acid
• N-acetylaspartate
• Creatine
• Choline

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Aspartic Acid (analogs & derivatives, analysis)
• Biomarkers, Tumor (analysis)
• Brain Chemistry
• Brain Neoplasms (chemistry, diagnosis)
• Choline (analysis)
• Creatine (analysis)
• Diagnosis, Differential
• Female
• Humans
• Magnetic Resonance Spectroscopy (methods)
• Male
• Middle Aged
• Protons
• Reproducibility of Results
• Sensitivity and Specificity
• Young Adult