Abstract | BACKGROUND:
Acute chest syndrome (ACS) represents a serious morbidity and often fatal complication in patients with sickle cell disease. Painful episodes which require hospitalization are most often treated with opioids, which may then influence the development of ACS. Nalbuphine is a parenteral opioid which effectively treats pain and may cause less ACS. PROCEDURE: This retrospective chart review documented 988 admissions for painful episodes at 2 institutions and recorded the incidence of ACS and opioid used. RESULTS: At the Children's Hospital in St Louis, Missouri, the incidence of ACS in patients treated with morphine alone was 10.8% versus at the Children's Mercy Hospital in Kansas City, Missouri, the incidence was 2.1% for patients treated solely with nalbuphine. CONCLUSIONS:
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Authors | Karen Lewing, Kristen Britton, Michael DeBaun, Gerald Woods |
Journal | Journal of pediatric hematology/oncology
(J Pediatr Hematol Oncol)
Vol. 33
Issue 4
Pg. 255-60
(May 2011)
ISSN: 1536-3678 [Electronic] United States |
PMID | 21464764
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Narcotics
- Morphine
- Nalbuphine
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Topics |
- Acute Disease
- Adolescent
- Anemia, Sickle Cell
(epidemiology)
- Chest Pain
(chemically induced, drug therapy, epidemiology)
- Child
- Child, Preschool
- Choice Behavior
- Female
- Humans
- Incidence
- Male
- Morbidity
- Morphine
(administration & dosage, adverse effects)
- Nalbuphine
(administration & dosage, adverse effects)
- Narcotics
(administration & dosage, adverse effects)
- Parents
- Retrospective Studies
- Young Adult
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