Abstract | BACKGROUND: 2-¹⁸fluoro-deoxy-D-glucose positron emission tomography (FDG-PET) has been recommended in international guidelines in the evaluation of postchemotherapy seminoma residuals. Our trial was designed to validate these recommendations in a larger group of patients. PATIENTS AND METHODS: FDG-PET studies in patients with metastatic seminoma and residual masses after platinum-containing chemotherapy were correlated with either the histology of the resected lesion(s) or the clinical outcome. RESULTS: One hundred and seventy seven FDG-PET results were contributed. Of 127 eligible PET studies, 69% were true negative, 11% true positive, 6% false negative, and 15% false positive. We compared PET scans carried out before and after a cut-off level of 6 weeks after the end of the last chemotherapy cycle. PET sensitivity, specificity, negative predictive value (NPV), and positive predictive value were 50%, 77%, 91%, and 25%, respectively, before the cut-off and 82%, 90%, 95%, and 69% after the cut-off. PET accuracy significantly improved from 73% before to 88% after the cut-off (P=0.032). CONCLUSION: Our study confirms the high specificity, sensitivity, and NPV of FDG-PET for evaluating postchemotherapy seminoma residuals. When carried out at an adequate time point, FDG-PET remains a valuable tool for clinical decision-making in this clinical setting and spares patients unnecessary therapy.
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Authors | M Bachner, Y Loriot, M Gross-Goupil, P A Zucali, A Horwich, J-R Germa-Lluch, C Kollmannsberger, F Stoiber, A Fléchon, K Oechsle, S Gillessen, J Oldenburg, G Cohn-Cedermark, G Daugaard, F Morelli, A Sella, S Harland, M Kerst, J Gampe, C Dittrich, K Fizazi, M De Santis |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 23
Issue 1
Pg. 59-64
(Jan 2012)
ISSN: 1569-8041 [Electronic] England |
PMID | 21460378
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Validation Study)
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Chemical References |
- Radiopharmaceuticals
- 2-fluoro-2-deoxyglucose-6-phosphate
- Glucose-6-Phosphate
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Topics |
- Glucose-6-Phosphate
(analogs & derivatives)
- Humans
- Male
- Positron-Emission Tomography
- Radiopharmaceuticals
- Retrospective Studies
- Seminoma
(diagnostic imaging)
- Sensitivity and Specificity
- Testicular Neoplasms
(diagnostic imaging)
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