Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: AIM OF THE STUDY: The present study was to evaluate the protective effect of sophocarpine on the inhibition of NF-kappaB (NF-κB) and effect on inflammatory markers during myocardial ischemia-reperfusion (I/R) injury in rat. MATERIALS AND METHODS: Myocardial I/R injury was induced by the occlusion of left anterior descending coronary artery for 30 min followed by reperfusion for 2 h. 2 h after reperfusion was established, the hemodynamics and infarct size were examined. Blood samples were collected for biochemical analysis. Expression of NF-κB and mitogen-activated protein kinases (MAPKs) in ischemic myocardial tissue were assayed by western blot. RESULTS: CONCLUSIONS: Inflammatory mediators, infiltration of neutrophil, and MPO were ameliorated via down-regulation of JNK and p38, and inactivation of NF-κB. This might be one of the important mechanisms of sophocarpine that protected myocardial injury from I/R.
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Authors | Chunmei Li, Yonglin Gao, Jingwei Tian, Jingyu Shen, Yanli Xing, Zhifeng Liu |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 135
Issue 3
Pg. 620-5
(Jun 01 2011)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 21459139
(Publication Type: Journal Article)
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Copyright | Copyright © 2011. Published by Elsevier Ireland Ltd. |
Chemical References |
- Alkaloids
- Anti-Inflammatory Agents
- Inflammation Mediators
- NF-kappa B
- Plant Extracts
- sophocarpine
- Peroxidase
- Mitogen-Activated Protein Kinases
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Topics |
- Alkaloids
(isolation & purification, pharmacology, therapeutic use)
- Animals
- Anti-Inflammatory Agents
(isolation & purification, pharmacology, therapeutic use)
- Biological Transport
(drug effects)
- Coronary Occlusion
- Heart
(drug effects, physiopathology)
- Inflammation Mediators
(metabolism)
- Mitogen-Activated Protein Kinases
(metabolism)
- Myocardial Infarction
(metabolism, pathology, prevention & control)
- Myocardial Reperfusion Injury
(metabolism, pathology, prevention & control)
- Myocardium
(metabolism, pathology)
- NF-kappa B
(antagonists & inhibitors)
- Neutrophils
(metabolism)
- Peroxidase
(metabolism)
- Phytotherapy
- Plant Extracts
(chemistry, pharmacology, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Seeds
- Sophora
(chemistry)
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