Ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro.

Abstract

Many plants are used in Ayurveda for the treatment of tuberculosis. Our aim was to examine if these plants possess any specific molecule that inhibits Mycobacterium tuberculosis. One of them, Kaempferia galanga, yielded an anti-TB molecule, ethyl p-methoxycinnamate (EPMC). By resazurin microtitre assay (REMA), EPMC was shown to inhibit M. tuberculosis H37Ra, H37Rv, drug susceptible and multidrug resistant (MDR) clinical isolates (MIC 0.242-0.485mM). No cross resistance was observed to any standard anti-TB drugs in the MDR strains. The compound did not inhibit any prototype bacteria tested. EPMC seems to be a potential anti-TB lead molecule.

• Authors: Divya Lakshmanan, Jim Werngren, Leny Jose, K P Suja, Mangalam S Nair, R Luxmi Varma, Sathish Mundayoor, Sven Hoffner, R Ajay Kumar
• Journal: Fitoterapia (Fitoterapia) Vol. 82 Issue 5 Pg. 757-61 (Jul 2011) ISSN: 1873-6971 [Electronic] Netherlands
• PMID: 21459133 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier B.V. All rights reserved.

Chemical References

• Antitubercular Agents
• Cinnamates
• Plant Extracts
• ethyl 4-methoxycinnamate

Topics

• Antitubercular Agents (isolation & purification, pharmacology)
• Cinnamates (isolation & purification, pharmacology)
• Drug Resistance (drug effects)
• Microbial Sensitivity Tests
• Mycobacterium tuberculosis (drug effects)
• Plant Extracts (chemistry, pharmacology)
• Rhizome
• Zingiberaceae (chemistry)