HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Melatonin administration after pilocarpine-induced status epilepticus: a new way to prevent or attenuate postlesion epilepsy?

AbstractOBJECTIVE:
The goal of this study was to verify the effects of treatment with melatonin and N-acetylserotonin on the pilocarpine-induced epilepsy model.
METHODS:
The animals were divided into four groups: (1) animals treated with saline (Saline); (2) animals that received pilocarpine and exhibited SE (SE); (3) animals that exhibited SE and were treated with N-acetylserotonin (30 minutes and 1, 2, 4, 6, 12, 24, 36, and 48 hours) after SE onset (SE+NAS); (4) animals that exhibited SE and were treated with melatonin at the same time the SE+NAS group (SE+MEL). Behavioral (latency to first seizure, frequency of seizures, and mortality) and histological (Nissl and neo-Timm) parameters were analyzed.
RESULTS:
The animals treated with melatonin (SE+MEL) had a decreased number of spontaneous seizures during the chronic period (P<0.05), a reduction in mossy fiber sprouting, and less cell damage than the SE group. Animals treated with N-acetylserotonin did not exhibit any kind of significant change.
CONCLUSION:
Melatonin exerts an important neuroprotective effect by attenuating SE-induced postlesion and promoting a decrease in the number of seizures in epileptic rats. This suggests, for the first time, that melatonin could be used co-therapeutically in treatment of patients exhibiting SE to minimize associated injuries in these situations.
AuthorsEliângela Lima, Francisco R Cabral, Esper A Cavalheiro, Maria da Graça Naffah-Mazzacoratti, Débora Amado
JournalEpilepsy & behavior : E&B (Epilepsy Behav) Vol. 20 Issue 4 Pg. 607-12 (Apr 2011) ISSN: 1525-5069 [Electronic] United States
PMID21454134 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011. Published by Elsevier Inc.
Chemical References
  • Antioxidants
  • Pilocarpine
  • Serotonin
  • Melatonin
  • N-acetylserotonin
Topics
  • Analysis of Variance
  • Animals
  • Antioxidants (administration & dosage)
  • Cell Death (drug effects)
  • Disease Models, Animal
  • Hippocampus (drug effects, pathology)
  • Male
  • Melatonin (administration & dosage)
  • Pilocarpine
  • Rats
  • Rats, Wistar
  • Serotonin (administration & dosage, analogs & derivatives)
  • Statistics as Topic
  • Status Epilepticus (chemically induced, drug therapy, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: