Abstract | OBJECTIVE: METHODS: The animals were divided into four groups: (1) animals treated with saline (Saline); (2) animals that received pilocarpine and exhibited SE (SE); (3) animals that exhibited SE and were treated with N-acetylserotonin (30 minutes and 1, 2, 4, 6, 12, 24, 36, and 48 hours) after SE onset (SE+NAS); (4) animals that exhibited SE and were treated with melatonin at the same time the SE+NAS group (SE+MEL). Behavioral (latency to first seizure, frequency of seizures, and mortality) and histological (Nissl and neo-Timm) parameters were analyzed. RESULTS: The animals treated with melatonin (SE+MEL) had a decreased number of spontaneous seizures during the chronic period (P<0.05), a reduction in mossy fiber sprouting, and less cell damage than the SE group. Animals treated with N-acetylserotonin did not exhibit any kind of significant change. CONCLUSION:
Melatonin exerts an important neuroprotective effect by attenuating SE-induced postlesion and promoting a decrease in the number of seizures in epileptic rats. This suggests, for the first time, that melatonin could be used co-therapeutically in treatment of patients exhibiting SE to minimize associated injuries in these situations.
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Authors | Eliângela Lima, Francisco R Cabral, Esper A Cavalheiro, Maria da Graça Naffah-Mazzacoratti, Débora Amado |
Journal | Epilepsy & behavior : E&B
(Epilepsy Behav)
Vol. 20
Issue 4
Pg. 607-12
(Apr 2011)
ISSN: 1525-5069 [Electronic] United States |
PMID | 21454134
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011. Published by Elsevier Inc. |
Chemical References |
- Antioxidants
- Pilocarpine
- Serotonin
- Melatonin
- N-acetylserotonin
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Topics |
- Analysis of Variance
- Animals
- Antioxidants
(administration & dosage)
- Cell Death
(drug effects)
- Disease Models, Animal
- Hippocampus
(drug effects, pathology)
- Male
- Melatonin
(administration & dosage)
- Pilocarpine
- Rats
- Rats, Wistar
- Serotonin
(administration & dosage, analogs & derivatives)
- Statistics as Topic
- Status Epilepticus
(chemically induced, drug therapy, pathology)
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