Abstract | OBJECTIVE: The aim of the current study was to determine the proportion of trigeminal primary afferent neurons that innervate the intracranial vasculature, and other craniofacial tissues, that are also 5 hydroxy triptamine (5-HT)(1D) receptor immunoreactive. METHODS: Retrograde tracing and immunohistochemistry was used to identify 5-HT(1D) receptor labeled trigeminal primary afferent neurons that innervate the lacrimal gland (n = 3 animals), nasal mucosa (n = 3 animals), and the intracranial vasculature (middle meningeal artery in the dura [n = 3 animals] and middle cerebral artery [n = 3 animals]). RESULTS: The percentage of neurons that were 5-HT(1D) receptor immunoreactive was greater for primary afferent neurons innervating the middle meningeal artery (41.8 ± 1%) than those innervating the middle cerebral artery (28.4 ± 0.8%), nasal mucosa (25.6 ± 1%), or lacrimal gland (23.5 ± 3%). For each retrograde labeled population, the 5-HT(1D) receptor immunoreactive cells were among the smallest of the retrograde labeled cells. CONCLUSIONS:
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Authors | Jason J Ivanusic, Matthew M K Kwok, Ernest A Jennings |
Journal | Headache
(Headache)
Vol. 51
Issue 5
Pg. 744-51
(May 2011)
ISSN: 1526-4610 [Electronic] United States |
PMID | 21453326
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 American Headache Society. |
Chemical References |
- Receptor, Serotonin, 5-HT1D
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Topics |
- Animals
- Immunohistochemistry
- Lacrimal Apparatus
(innervation)
- Male
- Middle Cerebral Artery
(innervation)
- Nasal Mucosa
(innervation)
- Neurons, Afferent
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Receptor, Serotonin, 5-HT1D
(biosynthesis)
- Trigeminal Ganglion
(metabolism)
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