Abstract |
A nearly two and a half year old boy was hospitalized after showing symptoms of disorientation and hallucination. The parents remembered the child playing with a bottle of Silomat cough drops, so that an intoxication was taken into consideration. After liquid/liquid extraction of a urine sample collected in hospital, the underivatized and the acetylated extracts were analyzed by gas chromatography-mass spectrometry (GC/MS) using electron ionization (EI) as well as chemical ionization (CI). In the urine sample high amounts of pentoxyverine ( carbetapentane) and several of its metabolites, e.g., different hydrolyzed, desalkylated and ring-hydroxylated products have been identified. The correlation of the results, the observed symptoms, and the access to the Silomat cough drops reveal an intoxication after ingestion of an unknown amount of the antitussive pentoxyverine. Corresponding EI- and CI-GC/MS spectra are presented characterizing the structure of its metabolites.
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Authors | F Westphal, Th Junge, L Radünz, J Stegk, G Rochholz |
Journal | Forensic science international
(Forensic Sci Int)
Vol. 215
Issue 1-3
Pg. 124-35
(Feb 10 2012)
ISSN: 1872-6283 [Electronic] Ireland |
PMID | 21450423
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Amino Alcohols
- Antitussive Agents
- Cyclopentanes
- clobutinol
- carbetapentane
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Topics |
- Amino Alcohols
(adverse effects, urine)
- Antitussive Agents
(adverse effects, urine)
- Child, Preschool
- Cyclopentanes
(urine)
- Forensic Toxicology
- Gas Chromatography-Mass Spectrometry
- Humans
- Male
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