GnRH stimulation test in precocious puberty: single sample is adequate for diagnosis and dose adjustment.

Abstract

OBJECTIVE:

Gonadotropin stimulation test is the gold standard to document precocious puberty. However, the test is costly, time-consuming and uncomfortable. The aim of this study was to simplify the intravenous gonadotropin-releasing hormone (GnRH) stimulation test in the diagnosis of precocious puberty and in the assessment of pubertal suppression.

METHODS:

Data pertaining to 584 GnRH stimulation tests (314 tests for diagnosis and 270 for assessment of pubertal suppression) were analyzed.

RESULTS:

Forty-minute post-injection samples had the greatest frequency of "peaking luteinizing hormone (LH)" (p<0.001) in the diagnostic tests when the cut-off value was taken as 5 IU/L for LH, 40th minute sample was found to have 98% sensitivity and 100% specificity in the diagnosis of precocious puberty, while the sensitivity and specificity of the 20th minute sample was 100% in the assessment of pubertal suppression.

CONCLUSION:

LH level at the 40th minute post-injection in the diagnosis of central precocious puberty and at the 20th minute post-injection in the assessment of pubertal suppression is highly sensitive and specific. A single sample at these time points can be used in the diagnosis of early puberty and in the assessment of pubertal suppression.

• Authors: Nurgün Kandemir, Hüseyin Demirbilek, Zeynep Alev Özön, Nazlı Gönç, Ayfer Alikaşifoğlu
• Journal: Journal of clinical research in pediatric endocrinology (J Clin Res Pediatr Endocrinol) Vol. 3 Issue 1 Pg. 12-7 ( 2011) ISSN: 1308-5735 [Electronic] Turkey
• PMID: 21448328 (Publication Type: Journal Article)
• Copyright: ©Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing.

Chemical References

• Gonadotropin-Releasing Hormone
• Luteinizing Hormone
• Follicle Stimulating Hormone

Topics

• Area Under Curve
• Child
• Female
• Follicle Stimulating Hormone (blood)
• Gonadotropin-Releasing Hormone
• Humans
• Luteinizing Hormone (blood)
• Puberty, Precocious (blood, diagnosis)
• ROC Curve
• Sensitivity and Specificity