EBV-positive plasmacytoma of the submandibular gland--report of a rare case with molecular genetic characterization.

Abstract

Plasmacytomas are differentiated plasma cell tumors that present as a mass lesion in osseous or extraosseous sites. Although the most common site for extramedullary plasmacytomas (EMP) is in the upper respiratory tract, plasmacytomas initially presenting as salivary gland masses are very uncommon. We describe a case of an EBV-positive plasmacytoma presenting as a 7.7 cm submandibular mass in an elderly immunocompetent man which displayed an abundance of "naked nuclei" on fine needle aspiration cytology. The tumor showed lambda light chain restriction and positive expression for CD38, MUM1 and EBER. Subsequent investigation for myeloma revealed absence of M-protein and end-organ damage, except for a lytic lesion in the radial bone. An extensive fluorescent in situ hybridization analysis showed the tumor to be negative for the t(4;14) FGFR3/IGH translocation as well as translocations involving the IGH, IGL, IGK, CCND1, BCL2, BCL6 and C-MYC genes. KRAS genetic analysis did not reveal any mutations of codons 12, 13 and 61.

• Authors: Benedict Yan, Soo Yong Tan, Ee Xuan Yau, Siok Bian Ng, Fredrik Petersson
• Journal: Head and neck pathology (Head Neck Pathol) Vol. 5 Issue 4 Pg. 389-94 (Dec 2011) ISSN: 1936-0568 [Electronic] United States
• PMID: 21442194 (Publication Type: Case Reports, Journal Article)

Chemical References

• Interferon Regulatory Factors
• interferon regulatory factor-4
• ADP-ribosyl Cyclase 1

Topics

• ADP-ribosyl Cyclase 1 (genetics, metabolism)
• Aged
• Biopsy, Fine-Needle
• Gene Expression Regulation, Neoplastic
• Herpesvirus 4, Human (isolation & purification)
• Humans
• Interferon Regulatory Factors (genetics, metabolism)
• Male
• Plasmacytoma (metabolism, pathology, virology)
• Submandibular Gland Neoplasms (metabolism, pathology, virology)