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Potent inhibitors of hepatitis C core dimerization as new leads for anti-hepatitis C agents.

Abstract
New indoline alkaloid-type compounds which inhibit HCV production by infected hepatoma cells have been identified. These compounds, dimeric-type compounds of previously known inhibitors, display double digit nanomolar IC(50) and EC(50) values, with cytotoxicity CC(50) indexes higher than 36 μM, thus providing ample therapeutic windows for further development of HCV drugs.
AuthorsFeng Ni, Smitha Kota, Virginia Takahashi, A Donny Strosberg, John K Snyder
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 21 Issue 8 Pg. 2198-202 (Apr 15 2011) ISSN: 1464-3405 [Electronic] England
PMID21440437 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
CopyrightCopyright © 2011 Elsevier Ltd. All rights reserved.
Chemical References
  • Alkaloids
  • Antiviral Agents
  • Indoles
  • Viral Core Proteins
  • nucleocapsid protein, Hepatitis C virus
  • indoline
Topics
  • Alkaloids (chemical synthesis, chemistry, toxicity)
  • Antiviral Agents (chemical synthesis, chemistry, toxicity)
  • Cell Line, Tumor
  • Dimerization
  • Hepacivirus (drug effects, metabolism)
  • Humans
  • Indoles (chemistry)
  • Viral Core Proteins (antagonists & inhibitors, metabolism)

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