Abstract |
New indoline alkaloid-type compounds which inhibit HCV production by infected hepatoma cells have been identified. These compounds, dimeric-type compounds of previously known inhibitors, display double digit nanomolar IC(50) and EC(50) values, with cytotoxicity CC(50) indexes higher than 36 μM, thus providing ample therapeutic windows for further development of HCV drugs.
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Authors | Feng Ni, Smitha Kota, Virginia Takahashi, A Donny Strosberg, John K Snyder |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 21
Issue 8
Pg. 2198-202
(Apr 15 2011)
ISSN: 1464-3405 [Electronic] England |
PMID | 21440437
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright © 2011 Elsevier Ltd. All rights reserved. |
Chemical References |
- Alkaloids
- Antiviral Agents
- Indoles
- Viral Core Proteins
- nucleocapsid protein, Hepatitis C virus
- indoline
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Topics |
- Alkaloids
(chemical synthesis, chemistry, toxicity)
- Antiviral Agents
(chemical synthesis, chemistry, toxicity)
- Cell Line, Tumor
- Dimerization
- Hepacivirus
(drug effects, metabolism)
- Humans
- Indoles
(chemistry)
- Viral Core Proteins
(antagonists & inhibitors, metabolism)
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