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Enhancement of the radiation effects by D-allose in head and neck cancer cells.

Abstract
The aim of this study was to investigate the radiosensitizing potential of D-allose in human head and neck cancer cells. HSC-3 cells were treated with or without D-allose for 6 h and then irradiated (2-6 Gy). The combination of D-allose and radiation was more effective than either agent alone. The radiation enhancement ratios at the 37% survival level were 1.61 and 2.11 for 10 mM and 25 mM D-allose treatment, respectively. The combination of D-allose and radiation also reduced the cell proliferation in 3D culture experiments. Although the mRNA expression of TXNIP was not increased by radiation alone, combined use with D-allose markedly elevated TXNIP expression. The combination of D-allose and radiation significantly induced intracellular reactive oxygen species (ROS) and apoptosis compared to that induced by either agent alone. This study shows that D-allose enhances the effect of radiation, suggesting a potential clinical application of combination treatment with D-allose and radiation for head and neck cancer.
AuthorsHiroshi Hoshikawa, Kanako Indo, Terushige Mori, Nozomu Mori
JournalCancer letters (Cancer Lett) Vol. 306 Issue 1 Pg. 60-6 (Jul 01 2011) ISSN: 1872-7980 [Electronic] Ireland
PMID21439723 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Carrier Proteins
  • RNA, Messenger
  • Reactive Oxygen Species
  • TXNIP protein, human
  • allose
  • Glucose
Topics
  • Apoptosis
  • Carrier Proteins (metabolism)
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Dose-Response Relationship, Drug
  • Glucose (chemistry, pharmacology)
  • Head and Neck Neoplasms (drug therapy, radiotherapy)
  • Humans
  • RNA, Messenger (metabolism)
  • Reactive Oxygen Species
  • Time Factors
  • Treatment Outcome

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