Abstract |
The aim of this study was to investigate the radiosensitizing potential of D- allose in human head and neck cancer cells. HSC-3 cells were treated with or without D- allose for 6 h and then irradiated (2-6 Gy). The combination of D- allose and radiation was more effective than either agent alone. The radiation enhancement ratios at the 37% survival level were 1.61 and 2.11 for 10 mM and 25 mM D- allose treatment, respectively. The combination of D- allose and radiation also reduced the cell proliferation in 3D culture experiments. Although the mRNA expression of TXNIP was not increased by radiation alone, combined use with D- allose markedly elevated TXNIP expression. The combination of D- allose and radiation significantly induced intracellular reactive oxygen species (ROS) and apoptosis compared to that induced by either agent alone. This study shows that D- allose enhances the effect of radiation, suggesting a potential clinical application of combination treatment with D- allose and radiation for head and neck cancer.
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Authors | Hiroshi Hoshikawa, Kanako Indo, Terushige Mori, Nozomu Mori |
Journal | Cancer letters
(Cancer Lett)
Vol. 306
Issue 1
Pg. 60-6
(Jul 01 2011)
ISSN: 1872-7980 [Electronic] Ireland |
PMID | 21439723
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Carrier Proteins
- RNA, Messenger
- Reactive Oxygen Species
- TXNIP protein, human
- allose
- Glucose
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Topics |
- Apoptosis
- Carrier Proteins
(metabolism)
- Cell Line, Tumor
- Cell Proliferation
- Cell Survival
- Dose-Response Relationship, Drug
- Glucose
(chemistry, pharmacology)
- Head and Neck Neoplasms
(drug therapy, radiotherapy)
- Humans
- RNA, Messenger
(metabolism)
- Reactive Oxygen Species
- Time Factors
- Treatment Outcome
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