Piperacillin/tazobactam versus cefozopran for the empirical treatment of pediatric cancer patients with febrile neutropenia.

Abstract

BACKGROUND:

The aim of this study was to evaluate the efficacy and safety of piperacillin/tazobactam (PIP/TAZO) and cefozopran (CZOP) monotherapy in pediatric cancer patients with febrile neutropenia (FN).

PROCEDURE:

A total of 119 febrile episodes in 49 neutropenic pediatric cancer patients (20 females and 29 males) with a median age of 6.8 years (range, 0.3-18.4 years) received randomized treatment either with PIP/TAZO 125 mg/kg every 8 hr or CZOP 25 mg/kg every 6 hr. Clinical response was determined at completion of therapy. Durations of fever and neutropenia, the need for modification of the therapy, and mortality rates were compared between the two groups.

RESULTS:

The frequency of success without modification of treatment was not significantly different between PIP/TAZO (59.6%) and CZOP (53.2%). Durations of fever and antibiotic therapy did not differ between the treatment groups, and no major side effects were observed in either group.

CONCLUSIONS:

PIP/TAZO and CZOP monotherapy were both effective and safe for the initial empirical treatment of pediatric cancer patients with FN.

• Authors: Mizuho Ichikawa, Daisuke Suzuki, Junjiro Ohshima, Yuko Cho, Makoto Kaneda, Akihiro Iguchi, Tadashi Ariga
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 57 Issue 7 Pg. 1159-62 (Dec 15 2011) ISSN: 1545-5017 [Electronic] United States
• PMID: 21438131 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2011 Wiley Periodicals, Inc.

Chemical References

• Anti-Bacterial Agents
• Cephalosporins
• Piperacillin, Tazobactam Drug Combination
• cefozopran
• Penicillanic Acid
• Piperacillin

Topics

• Adolescent
• Anti-Bacterial Agents (therapeutic use)
• Bacterial Infections (prevention & control)
• Cephalosporins (therapeutic use)
• Child
• Child, Preschool
• Female
• Fever (drug therapy, etiology)
• Humans
• Male
• Neoplasms (complications)
• Neutropenia (drug therapy, etiology)
• Penicillanic Acid (analogs & derivatives, therapeutic use)
• Piperacillin (therapeutic use)
• Piperacillin, Tazobactam Drug Combination