Abstract |
The Friend helper leukemia virus (F-MuLV) induces in mice leukemias of the erythroid, lymphoid, and myeloblastic lineages. Erythroleukemic cell DNAs were examined for genetic alterations at loci described as common proviral integration regions in MuLV-induced myeloid or lymphoid leukemias or in Friend complex-induced erythroleukemias. No alteration of the Fim-1, Fim-2, Fim-3, pvt-1, and Spi-1 loci were detected in 17 erythroleukemias, p53 gene rearrangement was observed in 6 (30%) erythroleukemias and was always associated with a loss of the germ line allele. Interestingly, genetic alterations were also detected at two loci, c-myc and Pim-1, previously described as common provirus integration regions in T lymphoid leukemias. Rearrangements of these two genes were often associated with p53 gene alteration within the same tumor.
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Authors | F Dreyfus, B Sola, S Fichelson, P Varlet, M Charon, P Tambourin, F Wendling, S Gisselbrecht |
Journal | Leukemia
(Leukemia)
Vol. 4
Issue 8
Pg. 590-4
(Aug 1990)
ISSN: 0887-6924 [Print] England |
PMID | 2143796
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA Probes
- Oncogene Proteins
- Phosphoproteins
- Tumor Suppressor Protein p53
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Topics |
- Animals
- Blotting, Northern
- Blotting, Southern
- DNA Probes
- Friend murine leukemia virus
- Gene Rearrangement
- Leukemia, Erythroblastic, Acute
(genetics)
- Mice
- Mice, Inbred Strains
- Oncogene Proteins
(genetics)
- Oncogenes
- Phosphoproteins
(genetics)
- Tumor Suppressor Protein p53
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