Neuroendocrine differentiation in a case of cervical cancer.

Abstract

Neuroendocrine neoplasms may occur in the uterine cervix, although rarely; it accounts for 0.5-1% of all malignant tumors of the uterine cervix. A case report of an Ethiopian female presented at the Gynecology Out-Patient Clinic at Jimma University Hospital, complaining from irregular vaginal bleeding over the previous three months. Clinically there was a cauliflower cervical mass; histopathologically it was formed of sheets of small cell tumor; that further showed neuroendocrine differentiation, as demonstrated by chromogranin-A positivity. It is important to differentiate small cell carcinoma from other malignant tumors of the uterine cervix. Morphological features play an important role in making a diagnosis and the immunohistochemistry study can offer an additional useful assistance.

• Authors: Mona Mohamed Rashed, Alemayehu Bekele
• Journal: The Pan African medical journal (Pan Afr Med J) Vol. 6 Pg. 4 (Jul 28 2010) ISSN: 1937-8688 [Electronic] Uganda
• PMID: 21436947 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers, Tumor

Topics

• Adult
• Biomarkers, Tumor
• Carcinoma, Neuroendocrine (pathology, surgery)
• Carcinoma, Small Cell (pathology, surgery)
• Diagnosis, Differential
• Female
• Humans
• Hysterectomy
• Hysterosalpingography
• Neoplasm Staging
• Ovariectomy
• Uterine Cervical Neoplasms (pathology, surgery)