Comparison of the immunosuppressive effects of dexamethasone, flunixin meglumine and meloxicam on the in vitro response of calf peripheral blood mononuclear cells.

Abstract	This study compared the immunosuppressive effects of dexamethasone (DEX), flunixin meglumine (FLU) and meloxicam (MEL) on the peripheral blood mononuclear cells (PBMCs) of seven healthy Holstein calves in vitro. DEX significantly inhibited lymphocyte proliferation and expression of interferon (IFN)-γ, interleukin (IL)-2 and IL-4 messenger RNA (mRNA) in comparison with FLU and MEL. FLU and MEL dose-dependently inhibited lymphocyte proliferation, but did not significantly reduce mRNA expression. Our in vitro study indicates that steroidal anti-inflammatory drugs (SAIDs) as well as nonsteroidal anti-inflammatory drugs (NSAIDs) have immunosuppressive effects on calf PBMCs. These findings are important for assessing the indications and complications of NSAIDs in calves.
Authors	Yousuke Maeda, Rie Tanaka, Hiromichi Ohtsuka, Keiici Matsuda, Taishi Tanabe, Masaaki Oikawa
Journal	The Journal of veterinary medical science (J Vet Med Sci) Vol. 73 Issue 7 Pg. 957-60 (Jul 2011) ISSN: 1347-7439 [Electronic] Japan
PMID	21436614 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Immunosuppressive Agents Interleukin-2 RNA, Messenger Thiazines Thiazoles Interleukin-4 Dexamethasone Interferon-gamma flunixin meglumine Clonixin Meloxicam
Topics	Animals Cattle (blood) Cell Proliferation (drug effects) Clonixin (analogs & derivatives, pharmacology) Dexamethasone (pharmacology) Female Immunosuppressive Agents (pharmacology) Interferon-gamma (blood, genetics, immunology) Interleukin-2 (blood, genetics, immunology) Interleukin-4 (blood, genetics, immunology) Leukocytes, Mononuclear (drug effects, immunology) Meloxicam RNA, Messenger (chemistry, genetics) Real-Time Polymerase Chain Reaction (veterinary) Reverse Transcriptase Polymerase Chain Reaction (veterinary) Thiazines (pharmacology) Thiazoles (pharmacology)

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