Abstract | BACKGROUND: OBJECTIVE: DATA SOURCES: MEDLINE, Embase, Scopus, Cochrane Register of Controlled Trials and citation review of relevant primary and review articles. STUDY SELECTION: DATA EXTRACTION: We abstracted data on study design, study setting, patient population, 28-day mortality or in-hospital mortality, rate of arrhythmias, hospital length of stay, and ICU length of stay. DATA SYNTHESIS: Six studies met our inclusion criteria. These studies included a total of 2043 participants, with 995 in the norepinephrine and 1048 in the dopamine groups. There were 479 (48%) deaths in the norepinephrine group and 555 (53%) deaths in the dopamine group. There was statistically significant superiority of norepinephrine over dopamine for the outcome of in-hospital or 28-day mortality: pooled RR: 0.91 (95% CI 0.83 to 0.99; P = .028). We also found a statistically significant decrease in the rate of cardiac arrhythmias in the norepinephine group as compared to the dopamine group: pooled RR: 0.43 (95% CI 0.26 to 0.69; P ≤ .001). A subgroup analysis that pooled studies in which all the randomized patients had septic shock demonstrated that norepinephrine improved in-hospital or 28-day mortality; however, the results were no longer statistically significant. CONCLUSIONS:
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Authors | Tajender S Vasu, Rodrigo Cavallazzi, Amyn Hirani, Gary Kaplan, Benjamin Leiby, Paul E Marik |
Journal | Journal of intensive care medicine
(J Intensive Care Med)
2012 May-Jun
Vol. 27
Issue 3
Pg. 172-8
ISSN: 1525-1489 [Electronic] United States |
PMID | 21436167
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
- Dopamine Agents
- Vasoconstrictor Agents
- Dopamine
- Norepinephrine
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Topics |
- Adult
- Dopamine
(therapeutic use)
- Dopamine Agents
(therapeutic use)
- Hospital Mortality
- Humans
- Intensive Care Units
- Length of Stay
- Norepinephrine
(therapeutic use)
- Randomized Controlled Trials as Topic
- Shock, Septic
(drug therapy, etiology)
- Vascular Resistance
(drug effects)
- Vasoconstrictor Agents
(therapeutic use)
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