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In vitro growth of urinary Escherichia coli related to siderophore production.

Abstract
Thirty seven strains of Escherichia coli isolated from the urine of patients with acute symptomatic urinary tract infection were examined for siderophore production: hydroxamate (aerobactin) and phenolate (enterochelin). All the strains were found to produce varying amounts of enterochelin. With the chemical assay, 24.3% strains were aerobactin producers, while 43.2% were positive in the bio-assay. All the aerobactin producers carried the aerobactin receptor on their surface. Attempts to correlate siderophore production with growth in minimal and iron-depleted medium showed that there was a positive quantitative correlation between enterochelin production and growth of organisms under iron depletion. Aerobactin production failed to give an additional advantage of growth to strains producing enterochelin.
AuthorsK Harjai, M Saxena, S Chhibber, S Sharma
JournalFolia microbiologica (Folia Microbiol (Praha)) Vol. 35 Issue 2 Pg. 149-54 ( 1990) ISSN: 0015-5632 [Print] United States
PMID2143166 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Bacterial Outer Membrane Proteins
  • Hydroxamic Acids
  • Iron Chelating Agents
  • Receptors, Immunologic
  • Siderophores
  • aerobactin receptor
  • aerobactin
  • Enterobactin
  • Serine
  • Iron
Topics
  • Bacterial Outer Membrane Proteins
  • Enterobactin (metabolism)
  • Escherichia coli (drug effects, growth & development, isolation & purification)
  • Escherichia coli Infections (microbiology)
  • Humans
  • Hydroxamic Acids (metabolism)
  • Iron (metabolism, pharmacology)
  • Iron Chelating Agents (metabolism)
  • Receptors, Immunologic (analysis)
  • Serine (analogs & derivatives)
  • Siderophores
  • Urinary Tract Infections (microbiology)

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