Abstract |
Thirty elderly patients suffering from macrocytic anaemia associated with chronic diseases were treated with folinic acid for 25 days at a dosage of 4-8 mg daily. For each patient routine laboratory tests have been carried out, the clinical parameters have been recorded at the beginning and at the end of the trial and after 8 days of treatment a possible reticulocyte crisis has been evaluated. The results showed a significant decrease of medium corpuscular volume (MCV), of mean corpuscular haemoglobin (MCH), of iron as well as an increase of folic acid in the serum. After 8 days of treatment a statistically significant reticulocyte crisis was observed.
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Authors | R Lucchi, A Criserà, M G Ferrari, A C Sacchetta |
Journal | La Clinica terapeutica
(Clin Ter)
Vol. 133
Issue 3
Pg. 159-63
(May 15 1990)
ISSN: 0009-9074 [Print] Italy |
Vernacular Title | L'acido folinico come terapia in pazienti anziani portatori di anemia macrocitica. |
PMID | 2142903
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Anemia, Macrocytic
(drug therapy)
- Drug Evaluation
- Female
- Humans
- Leucovorin
(therapeutic use)
- Male
- Middle Aged
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