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[Serum IgE and Fc epsilon receptor positive lymphocytes in atopic dermatitis--relation to the background of respiratory atopy].

Abstract
The serum IgE level and the population of Fc epsilon R2+ lymphocytes in peripheral blood of 62 patients with atopic dermatitis (AD) were studied. IgE was increased in the majority of the patients with personal or family history of asthma and/or allergic rhinitis (combined AD). On the contrary, only 63.2% of the patients who have solely AD (pure AD) showed less elevation of IgE. There was no correlation between IgE and the severity of dermatitis in pure AD and rhinitis combined AD. However, asthma combined AD showed a significant positive correlation between IgE and the severity of dermatitis. In AD, the population of Fc epsilon R2+ lymphocytes significantly correlated with IgE, suggesting that Fc epsilon R2+ lymphocytes may play a role in the enhanced synthesis of IgE. However, the increase of Fc epsilon R2+ lymphocytes was found only in combined AD, but not in pure AD. These results suggest that elevated IgE and Fc epsilon R2+ lymphocytes reflect combined respiratory atopy rather than AD itself, although there remains the possibility that IgE may influence the formation or exacerbation of dermatitis in asthma combined AD. As far as the participation of IgE is concerned, pure AD and asthma combined AD could be different groups and should be investigated separately.
AuthorsY Higaki
JournalNihon Hifuka Gakkai zasshi. The Japanese journal of dermatology (Nihon Hifuka Gakkai Zasshi) Vol. 100 Issue 4 Pg. 477-85 (Mar 1990) ISSN: 0021-499X [Print] Japan
PMID2142510 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antigens, Differentiation, B-Lymphocyte
  • Receptors, Fc
  • Receptors, IgE
  • Immunoglobulin E
Topics
  • Adolescent
  • Adult
  • Aged
  • Antigens, Differentiation, B-Lymphocyte (analysis)
  • Asthma (complications, immunology)
  • Child
  • Child, Preschool
  • Dermatitis, Atopic (complications, diagnosis)
  • Female
  • Humans
  • Immunoglobulin E (analysis)
  • Lymphocytes (immunology)
  • Male
  • Middle Aged
  • Receptors, Fc (analysis)
  • Receptors, IgE
  • Rhinitis (complications, immunology)
  • Severity of Illness Index

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