[Familial benign chronic pemphigus (Hailey-Hailey disease): successful treatment with carbon dioxide laser].

Abstract

Hailey-Hailey disease is a rare, autosomal dominantly inherited genodermatosis, which manifests with recurrent intraepidermal blistering and erythematous hyperkeratotic patches in intertriginous areas. Conventional therapeutic approaches include topical and systemic steroids, antibiotic agents, as well as oral retinoids. Alternative treatments include surgical interventions such as excision, dermabrasion and laser ablation. A 56-year-old woman presented with 15-year history of severe therapy-resistant Hailey-Hailey disease. We performed laser ablation with carbon dioxide laser under general anesthesia. Six weeks after treatment complete remission within ablated areas was achieved. Six-month follow-up showed no relapse. In our opinion carbon dioxide laser ablation represents an effective and safe therapeutic option for Hailey-Hailey disease.

• Authors: G Kukova, B Homey, D Bruch-Gerharz, E Diedrichson
• Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 62 Issue 4 Pg. 258-61 (Apr 2011) ISSN: 1432-1173 [Electronic] Germany
• Vernacular Title: Pemphigus chronicus benignus familiaris (Morbus Hailey-Hailey) : Erfolgreiche Behandlung mittels CO₂-Laser.
• PMID: 21424889 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Female
• Humans
• Lasers, Gas
• Low-Level Light Therapy (methods)
• Middle Aged
• Pemphigus, Benign Familial (pathology, radiotherapy)
• Treatment Outcome