Abstract |
Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. Activity of ATX is detected in various biological fluids. The lysophosphatidic acid (LPA) is the main product of ATX. LPA acting through specific G protein-coupled receptors (LPA(1)-LPA(6)) affects immunological response, normal development, and malignant tumors' formation and progression. In this review, the impact of autotoxin on biology of melanoma cells and potential treatment is discussed.
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Authors | Maciej Jankowski |
Journal | Enzyme research
(Enzyme Res)
Vol. 2011
Pg. 194857
(Mar 08 2011)
ISSN: 2090-0414 [Electronic] United States |
PMID | 21423677
(Publication Type: Journal Article)
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