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Autotaxin: its role in biology of melanoma cells and as a pharmacological target.

Abstract
Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. Activity of ATX is detected in various biological fluids. The lysophosphatidic acid (LPA) is the main product of ATX. LPA acting through specific G protein-coupled receptors (LPA(1)-LPA(6)) affects immunological response, normal development, and malignant tumors' formation and progression. In this review, the impact of autotoxin on biology of melanoma cells and potential treatment is discussed.
AuthorsMaciej Jankowski
JournalEnzyme research (Enzyme Res) Vol. 2011 Pg. 194857 (Mar 08 2011) ISSN: 2090-0414 [Electronic] United States
PMID21423677 (Publication Type: Journal Article)

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