Efficacy of aripiprazole in sulpiride-induced tardive oromandibular dystonia.

Abstract

Tardive dystonia is a side effect of dopamine receptor-blocking agents, which are mainly used as antipsychotic drugs. The treatment of tardive dystonia is difficult and often unsuccessful. An 82-year-old woman experienced mandibular deviation to the left due to spasm of the masticatory muscles with involuntary chewing movement and Parkinsonism. She had been treated with sulpiride for motility disorder for 5 years. Parkinsonism almost disappeared after the withdrawal of sulpiride, but tardive oromandibular dystonia showed no improvement. Aripiprazole treatment at 3 mg/day improved tardive oromandibular dystonia without worsening Parkinsonism. Low-dosage aripiprazole may be effective for tardive oromandibular dystonia in patients with no other psychiatric disorder.

• Authors: Noboru Imai, Masako Ikawa
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 50 Issue 6 Pg. 635-7 ( 2011) ISSN: 1349-7235 [Electronic] Japan
• PMID: 21422693 (Publication Type: Case Reports, Journal Article)

Chemical References

• Piperazines
• Quinolones
• Sulpiride
• Aripiprazole

Topics

• Aged, 80 and over
• Aripiprazole
• Dyskinesia, Drug-Induced (diagnosis, drug therapy)
• Female
• Humans
• Jaw (physiopathology)
• Movement Disorders (diagnosis, drug therapy)
• Piperazines (therapeutic use)
• Quinolones (therapeutic use)
• Sulpiride (adverse effects)