Successful remission of Evans syndrome associated with Graves' disease by using propylthiouracil monotherapy.

Abstract

A 46-year-old woman with Graves' disease was admitted for anemia and thrombocytopenia. She had previously been treated with methimazole but she self-discontinued the treatment 6 months prior to admission. She was diagnosed with Evans syndrome associated with Graves' disease and treated with propylthiouracil without corticosteroids, which normalized her thyroglobulin level. Surprisingly, while Evans syndrome is characterized by frequent relapses, this patient has been in remission of Evans syndrome for approximately 4 years. The remission of Evans syndrome associated with Graves' disease in the absence of immunosuppressive therapy suggests that these 2 diseases have a common pathogenetic mechanism.

• Authors: Takashi Ushiki, Masayoshi Masuko, Koji Nikkuni, Jun Terukina-Yoshida, Ayako Momotsu-Nanba, Hiroshi Morikawa, Akio Usami, Ichiro Fuse, Ken Toba, Kazue Takai, Yoshifusa Aizawa
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 50 Issue 6 Pg. 621-5 ( 2011) ISSN: 1349-7235 [Electronic] Japan
• PMID: 21422690 (Publication Type: Case Reports, Journal Article)

Chemical References

• Propylthiouracil

Topics

• Anemia, Hemolytic, Autoimmune (diagnosis, drug therapy)
• Female
• Graves Disease (diagnosis, drug therapy)
• Humans
• Propylthiouracil (therapeutic use)
• Thrombocytopenia (diagnosis, drug therapy)
• Treatment Outcome