Abstract | INTRODUCTION: MATERIALS AND METHODS: A total of 380 subjects were recruited to determine the genotypes of I/D polymorphisms of the ACE gene. Genotyping was performed using a PCR method. Statistical analyses were carried out using statistical software, and a level of p < 0.05 was considered statistically significant. RESULTS: The frequencies for II, ID and DD genotypes of the ACE gene were 24.7%, 65.80% and 9.47%, respectively, in ESRD patients, and in control subjects were 45.26%, 47.37% and 7.37% respectively. The frequency for the D allele was found to be higher (42.40%) in ESRD patients compared to control subjects (31.05%). The genotypic and allelic frequencies of I/D polymorphisms of the ACE gene differed significantly (p < 0.05) between ESRD patients and control subjects in the Malaysian population. CONCLUSION: The findings of this study indicate that I/D polymorphisms of the ACE gene are a useful marker and are likely to play a major role in determining genetic susceptibility to ESRD in the Malaysian population.
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Authors | Aisyah Ali, Ramachandran Vasudevan, Patimah Ismail, Christoper Lim Thiam Seong, Srikumar Chakravarthi |
Journal | Journal of the renin-angiotensin-aldosterone system : JRAAS
(J Renin Angiotensin Aldosterone Syst)
Vol. 16
Issue 4
Pg. 1337-43
(Dec 2015)
ISSN: 1752-8976 [Electronic] England |
PMID | 21421653
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2011. |
Chemical References |
- ACE protein, human
- Peptidyl-Dipeptidase A
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Topics |
- Adult
- Aged
- Case-Control Studies
- Electrophoresis, Agar Gel
- Female
- Gene Frequency
(genetics)
- Genetic Predisposition to Disease
- Heterozygote
- Humans
- INDEL Mutation
(genetics)
- Kidney Failure, Chronic
(enzymology, genetics)
- Malaysia
- Male
- Middle Aged
- Peptidyl-Dipeptidase A
(genetics)
- Polymorphism, Genetic
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