Abstract | PURPOSE: SETTING: Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. DESIGN: Randomized masked clinical trial. METHODS: In this paired-eye study, patients having bilateral PRK received 1 drop of diclofenac 0.1% in 1 eye and 1 drop of placebo in the fellow eye 2 hours before PRK. Postoperatively, both arms of the trial (both eyes of each patient) received topical diclofenac every 6 hours for 2 days. One day and 2 days postoperatively, patients were asked to rate the perceived pain in each eye using an 11-point verbal numerical rating scale. A trained examiner noted the eye-specific responses. RESULTS: All 70 patients (140 eyes) completed the study and were included in the statistical analysis. Twenty-four hours after PRK, patients reported pain scores that were clinically and statistically significantly lower in the eyes pretreated with diclofenac than in the fellow eyes (0.97 versus 2.09) (P=.018). Pain scores at 2 days did not differ significantly (P=.877). CONCLUSION: Administration of a single drop of topical diclofenac 0.1% 2 hours before PRK seemed to increase the efficacy of postoperative pain management in a clinically and statistically significant manner. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.
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Authors | Mehrdad Mohammadpour, Mahmood Jabbarvand, Mojgan Nikdel, Mohsen Adelpour, Nasser Karimi |
Journal | Journal of cataract and refractive surgery
(J Cataract Refract Surg)
Vol. 37
Issue 4
Pg. 633-7
(Apr 2011)
ISSN: 1873-4502 [Electronic] United States |
PMID | 21420586
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Diclofenac
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Topics |
- Administration, Topical
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Diclofenac
(administration & dosage)
- Double-Blind Method
- Eye Pain
(drug therapy)
- Female
- Humans
- Male
- Middle Aged
- Myopia
(surgery)
- Pain Measurement
- Pain, Postoperative
(drug therapy)
- Photorefractive Keratectomy
- Treatment Outcome
- Young Adult
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