Effect of preemptive topical diclofenac on postoperative pain relief after photorefractive keratectomy.

To assess the prophylactic effect of preoperative application of topical diclofenac on postoperative pain control in patients having photorefractive keratectomy (PRK).
Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Randomized masked clinical trial.
In this paired-eye study, patients having bilateral PRK received 1 drop of diclofenac 0.1% in 1 eye and 1 drop of placebo in the fellow eye 2 hours before PRK. Postoperatively, both arms of the trial (both eyes of each patient) received topical diclofenac every 6 hours for 2 days. One day and 2 days postoperatively, patients were asked to rate the perceived pain in each eye using an 11-point verbal numerical rating scale. A trained examiner noted the eye-specific responses.
All 70 patients (140 eyes) completed the study and were included in the statistical analysis. Twenty-four hours after PRK, patients reported pain scores that were clinically and statistically significantly lower in the eyes pretreated with diclofenac than in the fellow eyes (0.97 versus 2.09) (P=.018). Pain scores at 2 days did not differ significantly (P=.877).
Administration of a single drop of topical diclofenac 0.1% 2 hours before PRK seemed to increase the efficacy of postoperative pain management in a clinically and statistically significant manner.
No author has a financial or proprietary interest in any material or method mentioned.
AuthorsMehrdad Mohammadpour, Mahmood Jabbarvand, Mojgan Nikdel, Mohsen Adelpour, Nasser Karimi
JournalJournal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 37 Issue 4 Pg. 633-7 (Apr 2011) ISSN: 1873-4502 [Electronic] United States
PMID21420586 (Publication Type: Journal Article, Randomized Controlled Trial)
CopyrightCopyright © 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Diclofenac
  • Administration, Topical
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
  • Diclofenac (administration & dosage)
  • Double-Blind Method
  • Eye Pain (drug therapy)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myopia (surgery)
  • Pain Measurement
  • Pain, Postoperative (drug therapy)
  • Photorefractive Keratectomy
  • Treatment Outcome
  • Young Adult

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