[Retinal autofluorescence imaging in patients with pseudoxanthoma elasticum].

Abstract

PURPOSE:

To evaluate the autofluorescence findings in patients diagnosed with pseudoxanthoma elasticum.

MATERIAL AND METHODS:

A prospective study was conducted on 18 eyes of 9 patients who had ocular pathology andfollowed up in the pseudoxanthoma elasticum (PSX) unit of our hospital. We evaluated the best corrected visual acuity (BCVA), colour and autofluorescence photography (AF), and fluorescein angiography (FA) in patients with choroidal neovascularitation.

RESULTS:

Of the 9 patients, 7 were women and 2 were men. The mean age was 40 +/- 14 years. The BCVA ranged from 1 to 0.01 (Mean 0.65 +/- 0.4). All patients showed PSX injuries. Angioid streaks (AS) 18 (100%), peau d'orange 16 (87.5%) and pigmented fibrotic plates 5 (31,5%). We observed different hypoautofluorescence patterns (RPE atrophy), of which 2 of them were AS patterns (irregular lines with hyperautofluorescence speckled in its interior and edges, or bands with lobulated lesions inside and hyperautofluorescence at the edges), and finally widespread areas of hypoautofluorescence, larger than observed by ophthalmoscope.

CONCLUSIONS:

Autofluorescence in patients with PSX is an easy method to evaluate the initial level of ophthalmoscopic involvement and its subsequent progression. The extensive changes in the retinal pigment epithelium (RPE) suggests the important role of this in the physiopathology of the disease.

• Authors: M J Morillo, J Mora, A Soler, J M García-Campos, I García-Fernández, P Sánchez, P Valdivieso
• Journal: Archivos de la Sociedad Espanola de Oftalmologia (Arch Soc Esp Oftalmol) Vol. 86 Issue 1 Pg. 8-15 (Jan 2011) ISSN: 1989-7286 [Electronic] Spain
• Vernacular Title: Imágenes funduscópicas con autofluorescencia en pacientes con pseudoxantoma elástico.
• PMID: 21414524 (Publication Type: Journal Article)
• Copyright: 2010 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.

Chemical References

• Lipofuscin

Topics

• Adult
• Angioid Streaks (etiology, pathology)
• Atrophy
• Choroidal Neovascularization (etiology)
• Female
• Fibrosis
• Fluorescein Angiography
• Fluorescence
• Fluorometry
• Humans
• Lipofuscin (analysis, chemistry)
• Lysosomes (chemistry, ultrastructure)
• Male
• Middle Aged
• Ophthalmoscopy (methods)
• Prospective Studies
• Pseudoxanthoma Elasticum (diagnosis, diagnostic imaging, pathology)
• Radiography
• Retinal Pigment Epithelium (blood supply, pathology)
• Visual Acuity
• Young Adult