Measuring herpes zoster, zoster-associated pain, post-herpetic neuralgia-associated loss of quality of life, and healthcare utilization and costs in Thailand.

This study aimed to measure the herpes zoster-associated burden of illness, healthcare utilization, and costs among Thai patients.
This prospective cohort study of 180 patients aged ≥ 50 years and healthy, or ≥ 20 years and immunosuppressed, with zoster rash, was conducted in Bangkok and its environs, Thailand, during 2007-2008. Each patient was followed for six months for zoster-associated rash, pain, quality of life (QoL), and healthcare utilization and costs.
A total of 180 subjects were enrolled in the study. Their mean ± standard deviation (SD) age was 58.9 ± 13.8 years. Of the 180 patients enrolled, 138 (76.7%), 34 (18.9%) and eight (4.4%) patients were elderly, HIV-infected, and receiving immunosuppressive agents, respectively; 35 (19.4%) had post-herpetic neuralgia (PHN), and 13 (7.2%) had zoster ophthalmicus. The severity of zoster pain was moderately highly correlated with activities of daily living (ADL), at 0.68 ≤ ρ ≤ 0.76. Most patients required only one or two outpatient visits. The mean ± SD total of direct healthcare costs was 3083.4 ± 5047.0 Thai baht or ∼ 1.1% of annual income per capita.
Herpes zoster contributes a significant burden of illness to both patients and the wider community.
AuthorsKobkul Aunhachoke, Valai Bussaratid, Pornchai Chirachanakul, Boosbun Chua-Intra, Jittima Dhitavat, Kanokporn Jaisathaporn, Jaranit Kaewkungwal, Kowit Kampirapap, Thiravud Khuhaprema, Kulprapat Pairayayutakul, Punnee Pitisuttithum, Jirot Sindhvananda, Yupin Thaipisuttikul,
JournalInternational journal of dermatology (Int J Dermatol) Vol. 50 Issue 4 Pg. 428-35 (Apr 2011) ISSN: 1365-4632 [Electronic] United States
PMID21413953 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2011 The International Society of Dermatology.
Chemical References
  • AD 101
  • Immunosuppressive Agents
  • Piperazines
  • Niacinamide
  • Adult
  • Aged
  • Ambulatory Care (economics, utilization)
  • Cohort Studies
  • Female
  • Health Expenditures (statistics & numerical data)
  • Herpes Zoster (drug therapy, economics, epidemiology)
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Male
  • Middle Aged
  • Neuralgia, Postherpetic (drug therapy, economics, epidemiology)
  • Niacinamide (analogs & derivatives)
  • Piperazines
  • Prospective Studies
  • Quality of Life
  • Sick Leave (statistics & numerical data)
  • Socioeconomic Factors
  • Surveys and Questionnaires
  • Thailand (epidemiology)

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