[Effect of KP-136 on allergic paw edema in the rat].

Abstract

The pharmacological properties of KP-136, an inhibitor of type I allergy, were studied in rat paw models. In four allergic responses, three of the immediate type and one delayed type, KP-136 (p.o.) produced potent inhibitions on the mast cell-mediated type I allergy (ID30: 1.0 mg/kg) and the neutrophil-infiltrated passive Arthus reaction (ID30: 1.6 mg/kg). In addition, KP-136 (10 mg/kg, 50 mg/kg, p.o.) inhibited the injury of bone tissues in rat adjuvant arthritis, confirming that it was effective on the allergic inflammation with tissue injury. Although KP-136 was a weak inhibitor of carrageenin-induced paw edema, prostaglandin synthesis and complement-mediated hemolysis, the compound inhibited the release of lysosomal enzymes such as lysozyme and beta-glucuronidase in the passive Arthus reaction, suggesting the blockage of inflammatory mediator release for its mode of action.

• Authors: Y Hiyama, K Kuriyama
• Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 95 Issue 3 Pg. 83-90 (Mar 1990) ISSN: 0015-5691 [Print] Japan
• PMID: 2141318 (Publication Type: English Abstract, Journal Article)

Chemical References

• Azoles
• Chromones
• Immunosuppressive Agents
• Prostaglandins
• Tetrazoles
• KP 136
• Carrageenan

Topics

• Animals
• Arthritis (drug therapy)
• Arthritis, Experimental (drug therapy)
• Arthus Reaction (drug therapy)
• Azoles (therapeutic use)
• Carrageenan
• Chromones (pharmacology, therapeutic use)
• Edema (drug therapy)
• Hemolysis (drug effects)
• Hypersensitivity, Delayed (drug therapy)
• Hypersensitivity, Immediate (drug therapy)
• Immunosuppressive Agents (pharmacology, therapeutic use)
• Prostaglandins (biosynthesis)
• Rabbits
• Rats
• Rats, Inbred Lew
• Rats, Inbred Strains
• Tetrazoles (pharmacology, therapeutic use)