Corticosteroids in the treatment of severe nocardia pneumonia in chronic granulomatous disease.

Abstract

Nocardia is 1 of the 5 main pathogens that infect chronic granulomatous disease patients. Despite aggressive antimicrobial therapy, medical treatment is not always successful and surgical resection of infected tissue has been intermittently required. We present 2 chronic granulomatous disease patients with severe Nocardia pneumonia whose pulmonary status worsened despite appropriate antimicrobials, but then improved clinically and radiographically with the addition of corticosteroids.

• Authors: Alexandra F Freeman, Beatriz E Marciano, Victoria L Anderson, Gulbu Uzel, Christ Costas, Steven M Holland
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 30 Issue 9 Pg. 806-8 (Sep 2011) ISSN: 1532-0987 [Electronic] United States
• PMID: 21412179 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Intramural)

Chemical References

• Adrenal Cortex Hormones
• Anti-Bacterial Agents
• Anti-Inflammatory Agents

Topics

• Adolescent
• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Anti-Bacterial Agents (therapeutic use)
• Anti-Inflammatory Agents (therapeutic use)
• Granulomatous Disease, Chronic (complications, drug therapy)
• Humans
• Male
• Nocardia Infections (diagnosis, drug therapy, etiology)
• Pneumonia, Bacterial (diagnosis, drug therapy, etiology)
• Treatment Outcome
• Young Adult