Control generating of bacterial magnetic nanoparticle-doxorubicin conjugates by poly-L-glutamic acid surface modification.

Abstract

By using poly-L-glutamic acid (PLGA) to modify the membrane surface of bacterial magnetic nanoparticles (BMPs), (BMP)-doxorubicin conjugates (DBMP-P) could be control generated. The doxorubicin loading ratio could be raised up to 81.7% (w/w) in comparison with that of dual functional linkers. DBMP-P was characterized by transmission electron micrographs, attenuated total reflection infrared spectroscopy, magnetic properties, and dynamic light scattering. It is found that increase of the doxorubicin/PLGA modified BMP (PBMP) ratio leads to an increase of the drug loading ratio and a decrease of saturation magnetization. Besides, DBMP-P is sensitive to pH to facilitate drug release, shows enhancement of uptake by cancer cells, and is strongly cytotoxic to HePG2 and MCF-7 cells.

• Authors: Lin Guo, Ji Huang, Li-Min Zheng
• Journal: Nanotechnology (Nanotechnology) Vol. 22 Issue 17 Pg. 175102 (Apr 29 2011) ISSN: 1361-6528 [Electronic] England
• PMID: 21411921 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• Polyglutamic Acid
• Doxorubicin

Topics

• Antibiotics, Antineoplastic (administration & dosage, chemistry, pharmacokinetics, pharmacology)
• Cell Line, Tumor
• Doxorubicin (administration & dosage, chemistry, pharmacokinetics, pharmacology)
• Humans
• Magnetosomes (chemistry)
• Magnetospirillum (chemistry)
• Neoplasms (drug therapy)
• Polyglutamic Acid (chemistry)