Abstract | OBJECTIVE:
Diabetes mellitus type 1 (DM1) is associated with other autoimmune disorders. To our knowledge, there are no longitudinal data considering the long-term clinical relevance of organ-specific antibodies (OS-Ab) in DM1 patients. We performed a long-term retrospective longitudinal study in order to investigate the presence and diagnostic accuracy (positive predictive value: PPV and negative predictive value: NPV) of OS-Ab in DM1 patients. RESEARCH DESIGN AND METHODS: In a retrospective longitudinal study, the presence of OS-Ab and related organ function were analysed in 396 DM1 patients (184 F/212 M, age 44 ± 13 years, age at onset of DM1 21 ± 13 years), with a median follow-up time of 23 ± 10 years. RESULTS: OS-Ab frequencies at baseline were: antibodies against thyroglobulin (Tg-Ab) 4.3%, antibodies against thyroid peroxidase (TPO-Ab) 8.1%, Tg- and/or TPO-Ab 10.4%, antibodies against parietal cells (PCA) 5.8% and antibodies against adrenal cortex (ACA) 0.5%. The occurrence of (sub)clinical hypothyroidism was higher in patients with Tg- Ab (47%) or TPO-Ab (42%) than in those without these antibodies (6.2 and 5.1%, respectively, p<0.001). PPV and NPV for Tg-Ab were 0.60 and 0.88, respectively, for TPO -Ab 0.54 and 0.91. Also in patients with PCA, organ dysfunction occurred more often (61%) than in patients without PCA (9.7%, p<0.001). PPV for PCA was 0.61 and NPV 0.90. NPV and PPV for ACA could not be calculated because of the low prevalence. CONCLUSION: Long-term follow-up of 396 DM1 patients shows that the presence of thyroid antibodies and/ or parietal cell antibodies is clearly associated with dysfunction of the corresponding organ.
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Authors | L C G de Graaff, P Martín-Martorell, J Baan, B Ballieux, J W A Smit, J K Radder |
Journal | The Netherlands journal of medicine
(Neth J Med)
Vol. 69
Issue 2
Pg. 66-71
(Feb 2011)
ISSN: 1872-9061 [Electronic] Netherlands |
PMID | 21411842
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Age of Onset
- Aged
- Autoantibodies
(immunology)
- Autoimmune Diseases
(epidemiology, immunology)
- Child
- Comorbidity
- Diabetes Mellitus, Type 1
(epidemiology, immunology)
- Female
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Netherlands
- Thyroid Gland
(immunology, physiopathology)
- Young Adult
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