Human autoantibodies against the 70-kd polypeptide of U1 small nuclear RNP are associated with HLA-DR4 among connective tissue disease patients.

Abstract

Serum samples from patients with connective tissue disease (CTD) were characterized using a recently developed enzyme-linked immunosorbent assay for reactivity with individual specific polypeptides of U1 small nuclear ribonucleoproteins, including the U1-70-kd protein. The distribution of HLA antigens was compared in CTD patients with and in those without anti-U1-70-kd autoantibodies and in normal controls. The frequencies of HLA-DR4 and HLA-DRw53 were increased among the anti-U1-70-kd autoantibody positive CTD group compared with the frequencies in anti-U1-70-kd autoantibody negative systemic lupus erythematosus patients and compared with normal controls. We conclude that the presence of autoantibodies reactive with the anti-U1-70-kd protein antigen is associated with HLA-DR4 and HLA-DRw53.

• Authors: R W Hoffman, L J Rettenmaier, Y Takeda, J E Hewett, I Pettersson, U Nyman, A M Luger, G C Sharp
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 33 Issue 5 Pg. 666-73 (May 1990) ISSN: 0004-3591 [Print] United States
• PMID: 2140681 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Antinuclear
• Autoantibodies
• HLA-DQ Antigens
• HLA-DR Antigens
• HLA-DR4 Antigen
• Ribonucleoproteins
• Ribonucleoproteins, Small Nuclear

Topics

• Antibodies, Antinuclear (analysis)
• Autoantibodies (analysis)
• Connective Tissue Diseases (immunology)
• Enzyme-Linked Immunosorbent Assay
• Female
• HLA-DQ Antigens (analysis)
• HLA-DR Antigens (analysis)
• HLA-DR4 Antigen (analysis)
• Humans
• Male
• Phenotype
• Ribonucleoproteins (immunology)
• Ribonucleoproteins, Small Nuclear