HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Phase I study of oral menogaril administered on a once weekly schedule.

Abstract
Forty-seven patients with solid tumors were treated on a phase I study of menogaril administered by mouth once per week. Nausea and vomiting were excessive at weekly doses of 350 and 450 mg/m2/week but were tolerable and controlled reasonably well by antiemetics at lower doses. There appeared to be a relatively shallow dose-vs-granulocytopenia curve above a menogaril dose of 180 mg/m2/week. No patient receiving chronic dexamethasone for cerebral edema developed granulocytopenia, even at menogaril doses of 350-450 mg/m2/week. Two patients developed neutropenic infection. No patient developed thrombocytopenia. Mild arrhythmias were seen in 3 patients. Two patients suffered possible myocardial infarcts that may not have been related to treatment. Asymptomatic blood pressure fluctuations were common and were probably not related to treatment. Diarrhea was dose-related but was generally not severe. Alopecia and stomatitis occurred occasionally. Minor responses were seen in two patients with gliomas, and three of five evaluable prostate cancer patients experienced marked pain relief. The dose recommended for phase II studies is 250-300 mg/m2/week with antiemetic pretreatment. This schedule appears to allow an oral menogaril dose-intensity that is approximately double that attainable with other oral schedules that have been studied.
AuthorsD J Stewart, S Verma, J A Maroun, L Robillard, R H Earhart
JournalInvestigational new drugs (Invest New Drugs) Vol. 8 Issue 1 Pg. 43-52 (Feb 1990) ISSN: 0167-6997 [Print] UNITED STATES
PMID2140564 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Menogaril
  • Nogalamycin
  • Daunorubicin
Topics
  • Administration, Oral
  • Adult
  • Antineoplastic Agents (administration & dosage, adverse effects, therapeutic use)
  • Daunorubicin (analogs & derivatives)
  • Drug Administration Schedule
  • Drug Evaluation
  • Female
  • Hematologic Diseases (chemically induced)
  • Humans
  • Male
  • Menogaril
  • Nogalamycin (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: