[A case of possible retroperitoneal metastasis of breast cancer successfully treated with oral S-1 and cyclophosphamide therapy after TC therapy].

We report a case of possible retroperitoneal metastasis of breast cancer successfully treated with oral S-1 and cyclophosphamide therapy after docetaxel and cyclophosphamide (TC) therapy. A 57-year-old woman with a history of bilateral breast cancer showed an increase in tumor markers during treatment with oral anastrozole as postoperative adjuvant therapy 4 years after her second cancer surgery. After careful examination, the patient was diagnosed as having multiple bone metastases and her medication was changed to oral letrozole. After 3 months, the patient developed left back pain and was referred to our hospital. CT scanning showed an enhanced mass in the region from the left perirenal and posterior pararenal spaces to the left psoas major muscle and the anterior aspect of the left iliacus muscle, suggesting retroperitoneal metastasis. TC therapy was performed and, as a result, tumor markers decreased and the mass disappeared on CT imaging. After discontinuation of TC therapy, the tumor markers increased again, following which oral S-1 and cyclophosphamide therapy were administered, and the tumor markers decreased. At the time of this writing, the patient is still undergoing therapy, and no recurrence has been observed. We concluded that oral S-1 and cyclophosphamide therapy were useful in the present case and were associated with few adverse effects.
AuthorsKimiyasu Yoneyama, Toshio Takeshita, Hiroshi Suzuki, Masaki Morise, Tetsutarou Suzuki, Shinya Kishi, Atsuko Tsutsui, Akiko Matsumoto
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 3 Pg. 435-7 (Mar 2011) ISSN: 0385-0684 [Print] Japan
PMID21403449 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Drug Combinations
  • Taxoids
  • S 1 (combination)
  • Tegafur
  • docetaxel
  • Oxonic Acid
  • Cyclophosphamide
  • Administration, Oral
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
  • Breast Neoplasms (drug therapy, pathology, surgery)
  • Combined Modality Therapy
  • Cyclophosphamide (administration & dosage, therapeutic use)
  • Drug Combinations
  • Female
  • Humans
  • Middle Aged
  • Oxonic Acid (administration & dosage, therapeutic use)
  • Retroperitoneal Neoplasms (drug therapy, secondary)
  • Taxoids (administration & dosage, therapeutic use)
  • Tegafur (administration & dosage, therapeutic use)
  • Tomography, X-Ray Computed

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