Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Rhizoma Pinelliae Praeparatum is the product of raw Rhizoma Pinellia processed with alkaline solution and Licorice, which had been widely used for treatment of insomnia in traditional Chinese medicine. The present study aimed to investigate the sedative, hypnotic and anticonvulsant activities of ethanol fraction from Rhizoma Pinelliae Praeparatum (EFRP) and to determine whether these effects were related to GABAergic mechanism. MATERIALS AND METHODS: RESULTS: EFRP at dose of 12 g/kg significantly inhibited the locomotion activity of mice. EFRP showed synergic effect on pentobarbital-induced sleeping by increased numbers of mice falling asleep, reduced the sleep latency and prolonged the sleeping time. L- malic acid and flumazenil inhibited the augment effects of EFRP on pentobarbital-induced sleeping. EFRP promoted a significant protection to NKTM-induced convulsion, by prolonged the death latency and decreased mortality. CONCLUSION:
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Authors | Xiang-yang Wu, Jiang-li Zhao, Min Zhang, Fang Li, Ting Zhao, Liu-qing Yang |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 135
Issue 2
Pg. 325-9
(May 17 2011)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 21402138
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Anticonvulsants
- Hypnotics and Sedatives
- Plant Extracts
- Nikethamide
- Ethanol
- Pentobarbital
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Topics |
- Animals
- Anticonvulsants
(pharmacology, therapeutic use)
- Ethanol
(chemistry)
- Hypnotics and Sedatives
(pharmacology)
- Locomotion
(drug effects)
- Mice
- Mice, Inbred ICR
- Nikethamide
(administration & dosage)
- Pentobarbital
(administration & dosage)
- Pinellia
(chemistry)
- Plant Extracts
(pharmacology)
- Seizures
(chemically induced, drug therapy)
- Sleep
(drug effects)
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