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Protective effects of MLIF analogs on cerebral ischemia-reperfusion injury in rats.

Abstract
The monocyte locomotion inhibitory factor (MLIF) is an anti-inflammatory oligopeptide produced by Entamoeba histolytica. Among its different effects, it inhibits locomotion of human monocytes, hence its original name. The carboxyl-terminal end group Cys-Asn-Ser is the pharmacophore of anti-inflammatory peptide Met-Gln-Cys-Asn-Ser. In this study, the N-terminal of Cys-Asn-Ser was modified. With the aim to enhance the antioxidant ability and penetrability of Cys-Asn-Ser, we designed and synthesized two tetrapeptides Tyr-Cys-Asn-Ser and His-Cys-Asn-Ser. The neuroprotective effects of Tyr-Cys-Asn-Ser and His-Cys-Asn-Ser on focal ischemia reperfusion were investigated, and their pharmacological activities compared with Cys-Asn-Ser were studied. In order to study the mechanism of neuroprotective effect of these peptides, the level of oxidative stress markers malondialdehyde (MDA) and superoxide dismutase (SOD) and pro-inflammatory factors interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and myeloperoxidase (MPO) were detected in brain tissue homogenate.
AuthorsJia Yao, Ying Xu, Fang Ji, Chao Wang, Yun Zhang, Jingman Ni, Rui Wang
JournalPeptides (Peptides) Vol. 32 Issue 5 Pg. 1047-54 (May 2011) ISSN: 1873-5169 [Electronic] United States
PMID21402115 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Inc. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Interleukin-1beta
  • Oligopeptides
  • Tumor Necrosis Factor-alpha
  • monocyte locomotion inhibitory factor
  • Malondialdehyde
  • Superoxide Dismutase
Topics
  • Animals
  • Anti-Inflammatory Agents (chemistry, pharmacology, therapeutic use)
  • Brain Ischemia (drug therapy)
  • Cell Adhesion (drug effects)
  • Cell Movement (drug effects)
  • Enzyme-Linked Immunosorbent Assay
  • Interleukin-1beta (metabolism)
  • Male
  • Malondialdehyde (metabolism)
  • Oligopeptides (chemistry, pharmacology, therapeutic use)
  • Rats
  • Rats, Sprague-Dawley
  • Reperfusion Injury (drug therapy)
  • Superoxide Dismutase (metabolism)
  • Tumor Necrosis Factor-alpha (metabolism)

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