Vacuum-assisted closure therapy leads to an increase in plasma fibronectin level.

Abstract

An extensive research has been performed to investigate the mechanisms of action by which the application of subatmospheric pressure to wounds increases the rate of healing. Increased blood flow with vacuum-assisted closure (VAC) use is the most popular aspect. Fibronectin, which is an adhesion molecule, has several functional domains mediating chemotaxis, adhesion and migration. This is thereby involved in differentiation, proliferation, inflammation and thus in wound healing. In this study, plasma fibronectin levels were measured before and after VAC in patients with wounds. The results showed that there was an increase in pre- and post-VAC levels of plasma fibronectin. This statistically significant increase could be another explanation of how VAC therapy promotes wound healing.

• Authors: Emrah Arslan, Ozlem Goruroglu Ozturk, Alper Aksoy, Gurbuz Polat
• Journal: International wound journal (Int Wound J) Vol. 8 Issue 3 Pg. 224-8 (Jun 2011) ISSN: 1742-481X [Electronic] England
• PMID: 21401882 (Publication Type: Comparative Study, Journal Article)
• Copyright: © 2011 The Authors. © 2011 Blackwell Publishing Ltd and Medicalhelplines.com Inc.

Chemical References

• Biomarkers
• Fibronectins

Topics

• Adult
• Biomarkers (blood)
• Chronic Disease
• Female
• Fibronectins (blood, metabolism)
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Negative-Pressure Wound Therapy (methods)
• Risk Assessment
• Sampling Studies
• Severity of Illness Index
• Wound Healing (physiology)
• Wounds and Injuries (blood, etiology, surgery)