[Cycloferon efficacy of therapy of chronic hepatitis B (results of randomized multicentre study)].

Abstract

The best therapeutic effect in the treatment of patients with chronic hepatitis B was observed with the use of cycloferon in the scheme of the antiviral therapy. The combination of cycloferon with lamivudine provided complete stable remission in 54.1% of the patients, whereas the use of a-interferon in combination with cycloferon provided remission in 44.1% of the lamivudine-resistant patients. The use of cycloferon in the therapy of chronic hepatitis B made it possible to lower the frequency and manifestation level of the side effects and prevented the lamivudine resistance development and generation of the virus mutants.

• Authors: T V Sologub, A A Shul'diakov, L G Goriacheva, I P Baranova, Iu N Lin'kova, A L Kovalenko, M G Romantsov
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 55 Issue 9-10 Pg. 37-41 ( 2010) ISSN: 0235-2990 [Print] Russia (Federation)
• PMID: 21400753 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Acridines
• Interferon Inducers
• Reverse Transcriptase Inhibitors
• Lamivudine
• 10-carboxymethyl-9-acridanone

Topics

• Acridines (administration & dosage, therapeutic use)
• Administration, Oral
• Adult
• Drug Therapy, Combination
• Hepatitis B virus
• Hepatitis B, Chronic (drug therapy)
• Humans
• Injections, Intramuscular
• Interferon Inducers (administration & dosage, therapeutic use)
• Lamivudine (administration & dosage, therapeutic use)
• Reverse Transcriptase Inhibitors (administration & dosage, therapeutic use)
• Russia
• Treatment Outcome