Abstract | PURPOSE: SUBJECTS: This study evaluated 341 patients who had undergone a complete resection for stage I NSCLC between 2002 and 2008. RESULTS: The patients included 193 males and 148 females. The mean age of the patients was 69.2 years (range: 19-88). The histological types included 264 adenocarcinomas, 56 squamous cell carcinomas, 11 large cell carcinomas, and 10 other types of carcinoma. A pneumonectomy was performed in 2 patients, a bilobectomy in 7, a lobectomy in 255, a segmentectomy in 46, and partial resection of the lung in 31 patients. The positive rates for CYFRA 21-1 in the adenocarcinoma and squamous cell carcinoma patients were 33.3% and 76.8%, respectively. The positive rates for CEA in adenocarcinoma and squamous cell carcinoma patients were 23.8% and 26.8%, respectively. The 5-year survival rate after surgery in the normal CYFRA 21-1 group and the high CYFRA 21-1 groups were 92.8% and 75.4%, respectively, in the patients with stage I NSCLC. There was a significant difference between the 2 groups (p<0.0001). The 5-year survival rate according to the serum level of CEA in the patients with stage I NSCLC were 88.3% for the normal group and 76.3% for the high group. In a multivariate analysis using the variables found to be significant prognostic factors in univariate analysis, a high CYFRA 21-1 level was found to be a significant independent prognostic factor (95% confidence interval 1.213-5.442, p=0.014). CONCLUSION: A high preoperative CYFRA 21-1 level was a significant independent prognostic factor in patients with stage I NSCLC. The patients with a high CYFRA 21-1 level should carefully followed-up to rule out occult metastasis. Further clinical studies will be necessary to evaluate the efficacy of adjuvant therapy for the patients selected according to this criterion.
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Authors | Takeshi Hanagiri, Masakazu Sugaya, Masaru Takenaka, Sohich Oka, Tetsuro Baba, Yoshiki Shigematsu, Yoshika Nagata, Hidehiko Shimokawa, Hidetaka Uramoto, Mitsuhiro Takenoyama, Kosei Yasumoto, Fumihiro Tanaka |
Journal | Lung cancer (Amsterdam, Netherlands)
(Lung Cancer)
Vol. 74
Issue 1
Pg. 112-7
(Oct 2011)
ISSN: 1872-8332 [Electronic] Ireland |
PMID | 21397974
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Antigens, Neoplasm
- Biomarkers, Tumor
- Keratin-19
- Receptors, Cell Surface
- antigen CYFRA21.1
- carcinoembryonic antigen binding protein, human
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antigens, Neoplasm
(genetics, metabolism)
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Non-Small-Cell Lung
(diagnosis, mortality, pathology, physiopathology)
- Disease Progression
- Female
- Humans
- Keratin-19
(genetics, metabolism)
- Lung Neoplasms
(diagnosis, mortality, pathology, physiopathology)
- Male
- Middle Aged
- Neoplasm Staging
- Preoperative Care
- Prognosis
- Receptors, Cell Surface
(genetics, metabolism)
- Survival Analysis
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