Abstract | BACKGROUND: METHODS: RESULTS: Soluble mesothelin and osteopontin in serum and plasma were significantly elevated in MM patients compared to patients with benign lung and pleural disease. At a level of specificity of 95% relative to patients with benign disease, the sensitivity of mesothelin in serum and plasma at presentation with symptoms was 67%, and for osteopontin in the plasma was 40% and in the serum was 20% for MM patients. Combining the serum mesothelin and plasma osteopontin markers using a logistic regression model did not significantly increase the area under the receiver operator curve. CONCLUSION: Plasma osteopontin has a superior diagnostic accuracy to serum. As the choice of blood sample type has limit effect on soluble mesothelin sensitivity, plasma should be collected for biomarker evaluation in patients suspected of having mesothelioma.
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Authors | Jenette Creaney, Deborah Yeoman, Arthur William Musk, Nicholas de Klerk, Steven J Skates, Bruce W S Robinson |
Journal | Lung cancer (Amsterdam, Netherlands)
(Lung Cancer)
Vol. 74
Issue 1
Pg. 55-60
(Oct 2011)
ISSN: 1872-8332 [Electronic] Ireland |
PMID | 21397972
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Crown Copyright © 2011. Published by Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- GPI-Linked Proteins
- Osteopontin
- Mesothelin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(blood)
- Blood Specimen Collection
- Female
- GPI-Linked Proteins
(blood)
- Humans
- Lung Neoplasms
(diagnosis, pathology, physiopathology)
- Male
- Mesothelin
- Mesothelioma
(diagnosis, pathology, physiopathology)
- Middle Aged
- Osteopontin
(blood)
- Plasma
(metabolism)
- Predictive Value of Tests
- Prognosis
- Sensitivity and Specificity
- Serum
(metabolism)
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