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Sprayed intraperitoneal bupivacaine reduces early postoperative pain behavior and biochemical stress response after laparoscopic ovariohysterectomy in dogs.

Abstract
This study investigated the use of sprayed intraperitoneal bupivacaine to relieve postoperative pain behavior and biochemical stress response after laparoscopic ovariohysterectomy (LOVH) in dogs. Sixteen sexually intact female dogs were randomly assigned to two groups. The sprayed intraperitoneal bupivacaine (SIB) group received 4.4 mg/kg of sprayed intraperitoneal bupivacaine diluted to 0.25% with an equivalent volume of saline after pneumoperitoneum. The control group received 1.76 mL/kg of saline in a similar fashion. Both groups received preoperative periportal 5% bupivacaine (1 mL) before incision. Postoperative pain was measured using the short form of the Glasgow composite measures pain scale (CMPS-SF, 0-24). Serum cortisol and glucose concentrations were measured preoperatively and 0.5, 1, 2, 4, 6, 12, and 24h postoperatively. The SIB group had significantly lower CMPS-SF compared to the control group 1, 2, 4, 6, and 12h after the operation. Cortisol concentrations were significantly increased from preoperative concentrations in the control group at 0.5, 1, 2, and 4h post operation and at 0.5 and 1h post operation in the SIB group. No significant differences were seen in serum glucose within each group. This report suggests that the use of sprayed intraperitoneal bupivacaine can be used as part of a multimodal approach for pain management after LOVH in dogs.
AuthorsYoung K Kim, Scott S Lee, Euy H Suh, Lyon Lee, Hee C Lee, Hyo J Lee, Seong C Yeon
JournalVeterinary journal (London, England : 1997) (Vet J) Vol. 191 Issue 2 Pg. 188-92 (Feb 2012) ISSN: 1532-2971 [Electronic] England
PMID21397535 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Ltd. All rights reserved.
Chemical References
  • Anesthetics, Local
  • Bupivacaine
Topics
  • Administration, Topical
  • Anesthetics, Local (administration & dosage)
  • Animals
  • Bupivacaine (administration & dosage)
  • Dogs (physiology, surgery)
  • Female
  • Hysterectomy (veterinary)
  • Laparoscopy (veterinary)
  • Ovary (surgery)
  • Pain Measurement (veterinary)
  • Pain, Postoperative (prevention & control)
  • Peritoneum
  • Treatment Outcome

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