Xiao-Ban-Xia-Tang inhibits cisplatin-induced pica by down regulating obestatin in rats.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Xiao-Ban-Xia-Tang (XBXT), a traditional Chinese herbal medicine, has been used in China for more than 2000 years, and proved to be effective in various cases of vomiting in the clinic.

OBJECTIVE:

To investigate the inhibitive effect of XBXT on cisplatin-induced pica behaviour and its effective mechanism on obestatin, CCK and CGRP in the pica model of rat.

MATERIALS AND METHODS:

The inhibitive effect of XBXT was investigated in the pica model of rats induced by cisplatin (3mg kg(-1), i.p.) in 72h observation, the expression of obestatin in the area postrema and ileum was measured by immunohistochemistry and PCR, and the levels of CCK and CGRP in blood were measured by Elisa.

RESULTS:

The weight of kaolin eaten in rats induced by cisplatin was significantly reduced by pretreatment with XBXT in a dose-dependent manner during the 0-24h and 24-72h periods (P<0.05). XBXT exhibited effective dose-dependent (P<0.05) inhibition on the increase of expression levels of obestatin in both the ileum and area postrema, and markedly suppressed the increase levels of CCK and CGRP in blood induced by cisplatin in a dose-dependent manner (P<0.05).

CONCLUSIONS:

XBXT has good activity against cisplatin-induced eating kaolin in rats possibly by inhibiting central or peripheral increase of obestatin, or the levels of CCK and CGRP in blood.

• Authors: Qiuhai Qian, Wenhui Chen, Chunfang Guo, Wenguang Wu, Weibin Qian, Shuanglei Li
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 135 Issue 1 Pg. 186-93 (Apr 26 2011) ISSN: 1872-7573 [Electronic] Ireland
• PMID: 21396996 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antiemetics
• Antineoplastic Agents
• Drugs, Chinese Herbal
• Ghrelin
• xiao-ban-xia-tang
• Kaolin
• Cholecystokinin
• Calcitonin Gene-Related Peptide
• Cisplatin

Topics

• Animals
• Antiemetics (pharmacology, therapeutic use)
• Antineoplastic Agents (adverse effects)
• Area Postrema (metabolism)
• Calcitonin Gene-Related Peptide (blood)
• Cholecystokinin (blood)
• Cisplatin (adverse effects)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Down-Regulation
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Female
• Ghrelin (metabolism)
• Ileum (metabolism)
• Kaolin
• Phytotherapy
• Pica (chemically induced, prevention & control)
• Pinellia
• Rats
• Rats, Wistar
• Zingiberaceae