[Functional assessment of nigro-striatal pathway with FP-CIT in patients with multiple system atrophy subtype C].

Abstract

BACKGROUND AND OBJECTIVE:

To assess the functional state of nigro-striatal pathway using FP-CIT-I-123 in patients with clinical diagnosis of Multiple System Atrophy (MSA) subtype C.

PATIENTS AND METHODS:

We included 10 patients with a clinical diagnosis of MSA-C and compared them with 10 patients diagnosed with essential tremor (controls) and 10 with Parkinson Disease (PD). The studies are evaluated by the striatum/occipital index (S/O). We calculated the diagnostic validity of the procedure by ROC curve analysis.

RESULTS:

The average value of the S/O index showed a mean of 1.48 (0.23), 1.59 (0.17) and 1.22 (0.16) respectively for MSA-C, control group (p=0.25) and PD (p=0.00). ROC curve analysis: Az: 0.650; sensitivity: 0.50; specificity: 0.80. The comparison between the results of FP-CIT and clinical manifestations showed: 4 patients with parkinsonism (PK) and pathological study; 4 without PK and normal study; 1 with PK and normal study and 1 without PK and pathological study.

CONCLUSIONS:

FP-CIT study does not exclude completely the existence of an MSA-C. From a functional point of view, there does not always seem to be a consistency between the state of the nigro-striatal pathway and the existence of parkinsonism.

• Authors: María Dolores Martínez del Valle Torres, Esperanza Ramos Moreno, Tomader Amrani Raissouni, Simeón J Ortega Lozano, Salomé Sanz Viedma, José Manuel Jiménez-Hoyuela
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 137 Issue 10 Pg. 440-3 (Oct 15 2011) ISSN: 1578-8989 [Electronic] Spain
• Vernacular Title: Valoración funcional de la vía nigro-estriada mediante N-v-fluoropropil-2ßcarbometoxi-3ß-(4-Iodofenil) nortropano (FP-CIT) en pacientes con atrofia multisistémica subtipo cerebelosa.
• PMID: 21396668 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2010 Elsevier España, S.L. All rights reserved.

Chemical References

• Carbon Radioisotopes
• Dopamine Plasma Membrane Transport Proteins
• Fluorine Radioisotopes
• Iodine Radioisotopes
• Nerve Tissue Proteins
• Radiopharmaceuticals
• Tropanes
• 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane

Topics

• Aged
• Aged, 80 and over
• Carbon Radioisotopes (pharmacokinetics)
• Cerebellum (physiopathology)
• Corpus Striatum (chemistry, diagnostic imaging)
• Dopamine Plasma Membrane Transport Proteins (analysis)
• Essential Tremor (diagnostic imaging)
• Female
• Fluorine Radioisotopes (pharmacokinetics)
• Humans
• Iodine Radioisotopes (pharmacokinetics)
• Male
• Middle Aged
• Multiple System Atrophy (classification, complications, diagnostic imaging, metabolism)
• Nerve Tissue Proteins (analysis)
• Parkinson Disease (diagnostic imaging)
• Parkinsonian Disorders (diagnostic imaging, etiology)
• ROC Curve
• Radiopharmaceuticals (pharmacokinetics)
• Tomography, Emission-Computed, Single-Photon
• Tropanes (pharmacokinetics)