Abstract |
Pharmacokinetics of cefpodoxime in plasma (total concentration) and subcutaneous fluid (free concentration using microdialysis) was investigated in dogs following single oral administration of prodrug cefpodoxime proxetil (equivalent to 5 and 10 mg/kg of cefpodoxime). In a cross over study design, six dogs per dose were utilized after a 1 week washout period. Plasma, microdialysate, and urine samples were collected upto 24 h and analyzed using high performance liquid chromatography. The average maximum concentration (C(max) ) of cefpodoxime in plasma was 13.66 (±6.30) and 27.14 (±4.56) μg/mL with elimination half-life (t(1/2) ) of 3.01 (±0.49) and 4.72 (±1.46) h following 5 and 10 mg/kg dose, respectively. The respective average area under the curve (AUC(0-∞) ) was 82.94 (±30.17) and 107.71 (±30.79) μg·h/mL. Cefpodoxime was readily distributed to skin and average free C(max) in subcutaneous fluid was 1.70 (±0.55) and 3.06 (±0.93) μg/mL at the two doses. Urinary excretion (unchanged cefpodoxime) was the major elimination route. Comparison of subcutaneous fluid concentrations using pharmacokinetic/pharmacodynamic indices of fT(>MIC) indicated that at 10 mg/kg dose; cefpodoxime would yield good therapeutic outcome in skin infections for bacteria with MIC(50) upto 0.5 μg/mL while higher doses (or more frequent dosing) may be needed for bacteria with higher MICs. High urine concentrations suggested cefpodoxime use for urinary infections in dogs.
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Authors | V Kumar, R Madabushi, M B B Lucchesi, H Derendorf |
Journal | Journal of veterinary pharmacology and therapeutics
(J Vet Pharmacol Ther)
Vol. 34
Issue 2
Pg. 130-5
(Apr 2011)
ISSN: 1365-2885 [Electronic] England |
PMID | 21395603
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2010 Blackwell Publishing Ltd. |
Chemical References |
- Anti-Bacterial Agents
- cefpodoxime proxetil
- cefpodoxime
- Ceftizoxime
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Topics |
- Administration, Oral
- Animals
- Anti-Bacterial Agents
(administration & dosage, blood, pharmacokinetics)
- Area Under Curve
- Ceftizoxime
(administration & dosage, analogs & derivatives, blood, pharmacokinetics)
- Chromatography, High Pressure Liquid
(veterinary)
- Cross-Over Studies
- Dogs
(metabolism)
- Dose-Response Relationship, Drug
- Half-Life
- Injections, Subcutaneous
(veterinary)
- Male
- Random Allocation
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