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Differentiation of human kidney stones induced by melamine and uric acid using surface desorption atmospheric pressure chemical ionization mass spectrometry.

Abstract
Clinically obtained human kidney stones of different pathogenesis were dissolved in acetic acid/methanol solutions and then rapidly analyzed by surface desorption atmospheric pressure chemical ionization mass spectrometry (SDAPCI-MS) without any desalination treatment. The mass spectral fingerprints of six groups of kidney stone samples were rapidly recorded in the mass range of m/z 50-400. A set of ten melamine-induced kidney stone samples and nine uric acid derived kidney stone samples were successfully differentiated from other groups by principal component analysis of SDAPCI-MS fingerprints upon positive-ion detection mode. In contrast, the mass spectra recorded using negative-ion detection mode did not give enough information to differentiate those stone samples. The results showed that in addition to the melamine, the chemical compounds enwrapped in the melamine-induced kidney stone samples differed from other kidney stone samples, providing useful hints for studying on the formation mechanisms of melamine-induced kidney stones. This study also provides useful information on establishing a MS-based platform for rapid analysis of the melamine-induced human kidney stones at molecular levels.
AuthorsBin Jia, Yongzhong Ouyang, Rana N S Sodhi, Bin Hu, Tingting Zhang, Jianqiang Li, Huanwen Chen
JournalJournal of mass spectrometry : JMS (J Mass Spectrom) Vol. 46 Issue 3 Pg. 313-9 (Mar 2011) ISSN: 1096-9888 [Electronic] England
PMID21394847 (Publication Type: Journal Article)
CopyrightCopyright © 2011 John Wiley & Sons, Ltd.
Chemical References
  • Triazines
  • Uric Acid
  • melamine
Topics
  • Adult
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Kidney Calculi (chemically induced, chemistry, classification, metabolism)
  • Male
  • Mass Spectrometry (methods)
  • Middle Aged
  • Molecular Imaging
  • Principal Component Analysis
  • Triazines (chemistry, poisoning)
  • Uric Acid (chemistry)

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