Abstract | BACKGROUND: METHODS: RESULTS: Among the 2 gelatinase examined in vitreous and serum samples, only level and activity of MMP-9 were significantly higher in serum (P = 0.0001) and vitreous (P = 0.0002) samples of patients with ED than those of control subjects. Simultaneously, a positive correlation was found between intraocular tumor necrosis factor-α and MMP-9 concentration (Spearman correlation coefficient, r = 0.7040, P = 0.0023) in patients with ED. CONCLUSION: Increase in MMP-9 activity and its concentration in serum and vitreous of patients with ED compared with that of control subjects and correlation between intraocular levels of MMP-9 and tumor necrosis factor-α in patients with ED seem to provide a plausible explanation for inflammation-mediated angiogenesis during the development of this condition.
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Authors | Aditi Sen, Suman K Paine, Imran H Chowdhury, Amrita Mukherjee, Subhadip Choudhury, Lakshmi K Mandal, Basudev Bhattacharya |
Journal | Retina (Philadelphia, Pa.)
(Retina)
2011 Jul-Aug
Vol. 31
Issue 7
Pg. 1412-20
ISSN: 1539-2864 [Electronic] United States |
PMID | 21394064
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Tissue Inhibitor of Metalloproteinase-1
- Tumor Necrosis Factor-alpha
- Tissue Inhibitor of Metalloproteinase-2
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
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Topics |
- Adult
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Male
- Matrix Metalloproteinase 2
(blood)
- Matrix Metalloproteinase 9
(blood)
- Middle Aged
- Neovascularization, Pathologic
(blood, surgery)
- Retinal Neovascularization
(blood)
- Retinal Vasculitis
(blood, surgery)
- Tissue Inhibitor of Metalloproteinase-1
(blood)
- Tissue Inhibitor of Metalloproteinase-2
(blood)
- Tumor Necrosis Factor-alpha
(blood)
- Vitrectomy
- Vitreous Body
(metabolism)
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