Abstract | OBJECTIVE: This study investigated the effects of indole-3-carbinol (I3C), a cruciferous vegetable derivative, on obesity and its associated factors in high-fat-diet-induced obese (DIO) mice. METHODS: Eighteen male C57BL/6 mice were randomly assigned to one of three groups: basal, high fat (HF), and HF + 5 mg/kg of I3C intraperitoneally (HFI). After 12 wk of treatment, obesity-associated factors, including body weight, organ weight, serum concentrations of glucose, triacylglycerol, insulin, and adipokines, and macrophage accumulation and lipid metabolism-associated factors in epididymal adipose tissue were measured. RESULTS: CONCLUSION:
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Authors | Hsiao-Pei Chang, Mei-Lin Wang, Ming-Hsing Chan, Yen-Shuo Chiu, Yue-Hwa Chen |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 27
Issue 4
Pg. 463-70
(Apr 2011)
ISSN: 1873-1244 [Electronic] United States |
PMID | 21392705
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Adiponectin
- Anti-Obesity Agents
- Blood Glucose
- Dietary Fats
- Indoles
- Insulin
- Leptin
- PPAR gamma
- Plant Extracts
- RNA, Messenger
- Triglycerides
- indole-3-carbinol
- Acetyl-CoA Carboxylase
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Topics |
- Acetyl-CoA Carboxylase
(genetics, metabolism)
- Adiponectin
(blood)
- Adipose Tissue
(cytology, drug effects, metabolism)
- Animals
- Anti-Obesity Agents
(pharmacology, therapeutic use)
- Blood Glucose
(metabolism)
- Body Weight
(drug effects)
- Brassicaceae
(chemistry)
- Dietary Fats
(adverse effects)
- Glucose Intolerance
(drug therapy)
- Indoles
(pharmacology, therapeutic use)
- Insulin
(blood)
- Leptin
(blood)
- Male
- Mice
- Mice, Inbred C57BL
- Obesity
(blood, drug therapy, etiology)
- Organ Size
(drug effects)
- PPAR gamma
(metabolism)
- Phytotherapy
- Plant Extracts
(pharmacology, therapeutic use)
- RNA, Messenger
(metabolism)
- Triglycerides
(blood)
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